The Role of Metabolism in Heart Failure and Regeneration.
The Role of Metabolism in Heart Failure and Regeneration.
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DOI：
10.3389/fcvm.2021.702920
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发表时间：
2021
影响因子：
3.6
通讯作者：
Mahmoud AI
中科院分区：
文献类型：
--
作者：
Bae J;Paltzer WG;Mahmoud AI
心力衰竭是全世界死亡的主要原因。成年哺乳动物心脏受伤后无法再生，导致收缩性心力衰竭的发生。因此，确定成人心脏再生的新方法对于成人心力衰竭具有巨大的治疗潜力。线粒体代谢是维持生长和生存的重要稳态过程。线粒体代谢在控制细胞命运和功能中的新兴作用开始受到重视。最近的证据表明，新陈代谢控制着包括细胞增殖和分化在内的生物过程，这在发育和再生过程中具有深远的影响。哺乳动物心脏的再生潜力在出生后发育的第一周丧失，此时心肌细胞退出细胞周期并进行终末分化。这种损伤后无法再生的现象与出生后心脏成熟过程中发生的从糖酵解到脂肪酸氧化的代谢转变有关。因此，了解调节心脏代谢的机制是解锁发育、疾病和再生过程中代谢干预的关键。在这篇综述中，我们将重点关注代谢在心脏发育和再生中的新作用，并讨论靶向代谢治疗心力衰竭的潜力。
Heart failure is the leading cause of death worldwide. The inability of the adult mammalian heart to regenerate following injury results in the development of systolic heart failure. Thus, identifying novel approaches toward regenerating the adult heart has enormous therapeutic potential for adult heart failure. Mitochondrial metabolism is an essential homeostatic process for maintaining growth and survival. The emerging role of mitochondrial metabolism in controlling cell fate and function is beginning to be appreciated. Recent evidence suggests that metabolism controls biological processes including cell proliferation and differentiation, which has profound implications during development and regeneration. The regenerative potential of the mammalian heart is lost by the first week of postnatal development when cardiomyocytes exit the cell cycle and become terminally differentiated. This inability to regenerate following injury is correlated with the metabolic shift from glycolysis to fatty acid oxidation that occurs during heart maturation in the postnatal heart. Thus, understanding the mechanisms that regulate cardiac metabolism is key to unlocking metabolic interventions during development, disease, and regeneration. In this review, we will focus on the emerging role of metabolism in cardiac development and regeneration and discuss the potential of targeting metabolism for treatment of heart failure.
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影响因子：
13.8
作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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