Analyses of Kaposi Sarcoma trends among adults establishing initial outpatient HIV care in Nigeria: 2006-2017.
Analyses of Kaposi Sarcoma trends among adults establishing initial outpatient HIV care in Nigeria: 2006-2017.
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DOI：
10.1186/s13027-022-00424-4
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发表时间：
2022-03-21
影响因子：
3.7
通讯作者：
Murphy RL
中科院分区：
文献类型：
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作者：
Akanbi MO;Bilaver LA;Achenbach C;Hirschhorn LR;Rivera AS;Silas OA;Agaba PA;Agbaji O;Shehu NY;Sagay SA;Hou L;Murphy RL
The incidence of Human Immunodeficiency Virus (HIV)-associated Kaposi Sarcoma (KS) in the pre-antiretroviral therapy (ART) population remains high in several countries in sub-Saharan Africa. We examined trends of KS prevalence in adults, establishing initial outpatient HIV care from 2006 to 2017 in Nigeria. We analyzed data of 16,431 adults (age ≥ 18 years) enrolled for HIV care from January 1, 2006, to December 31, 2017, in a large clinic in Jos, Nigeria. KS at enrollment was defined as KS recorded in the electronic health record within 30 days of clinic enrollment. Time trends were compared among four periods: 2006–2008, 2009–2011, 2012–2014, and 2015–2017 using logistic regression models. Annual trends were analyzed using join point regression and restricted splines. The study population had a mean age 35.1 (standard deviation, SD 9.5) years, and were 65.7% female (n = 10,788). The mean CD4 cell count was 220 (95% CI 117–223). The overall KS prevalence at entry was 0.59% (95% CI 0.48–0.72). Compared to 2006–2008, KS prevalence was significantly higher in 2009–2011 (adjusted odds ratio 5.07 (95% CI 3.12–8.24), p < 0.001), but remained unchanged in subsequent periods. Male sex and low CD4 T-cell count independently increased odds for KS. Despite ART expansion, KS at enrollment showed no significant decline. The low CD4 cell count, across all periods, indicates delay in enrollment for HIV care, which increases KS risk. Interventions aimed at early HIV diagnosis and linkage to ART is critical to KS risk reduction in this population. The online version contains supplementary material available at 10.1186/s13027-022-00424-4.
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影响因子：
3.7
作者：
Losina E;Bassett IV;Giddy J;Chetty S;Regan S;Walensky RP;Ross D;Scott CA;Uhler LM;Katz JN;Holst H;Freedberg KA
通讯作者：
Freedberg KA
影响因子：
8.8
作者：
MACLEAN, C M
通讯作者：
MACLEAN, C M
影响因子：
3.7
作者：
Jahun I;Said I;El-Imam I;Ehoche A;Dalhatu I;Yakubu A;Greby S;Bronson M;Brown K;Bamidele M;Boyd AT;Bachanas P;Dirlikov E;Agbakwuru C;Abutu A;Williams-Sherlock M;Onotu D;Odafe S;Williams DB;Bassey O;Ogbanufe O;Onyenuobi C;Adeola A;Meribe C;Efuntoye T;Fagbamigbe OJ;Fagbemi A;Ene U;Nguhemen T;Mgbakor I;Alagi M;Asaolu O;Oladipo A;Amafah J;Nzelu C;Dakum P;Mensah C;Aliyu A;Okonkwo P;Oyeledun B;Oko J;Ikpeazu A;Gambo A;Charurat M;Ellerbrock T;Aliyu S;Swaminathan M
通讯作者：
Swaminathan M
影响因子：
2.2
作者：
Kay ES;Batey DS;Mugavero MJ
通讯作者：
Mugavero MJ
DOI：
10.1097/qai.0000000000001394
发表时间：
2017-08-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Dubrow R;Qin L;Lin H;Hernández-Ramírez RU;Neugebauer RS;Leyden W;Althoff KN;Achenbach CJ;Hessol NA;Modur SP;DʼSouza G;Bosch RJ;Grover S;Horberg MA;Kitahata MM;Mayor AM;Novak RM;Rabkin CS;Sterling TR;Goedert JJ;Justice AC;Engels EA;Moore RD;Silverberg MJ;North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS
通讯作者：
North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS