Histopathologic evaluation of basilar artery atherosclerosis.
Histopathologic evaluation of basilar artery atherosclerosis.
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DOI：
10.1016/j.jns.2011.05.004
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发表时间：
2011-08-15
影响因子：
4.4
通讯作者：
Fisher, Mark
中科院分区：
文献类型：
--
作者：
Labadzhyan, Artak;Csiba, Laszlo;Narula, Navneet;Zhou, Jun;Narula, Jagat;Fisher, Mark
对基底动脉粥样硬化的病理特征关注有限。人们一直认为基底动脉粥样硬化的病理与其他血管床的病理相似。为了明确基底动脉粥样硬化病变的性质，我们分析了8名卒中患者的死后颅内动脉样本。检查的7/8条动脉存在动脉粥样硬化病变，平均估计狭窄率为34%。1例可见纤维帽断裂的管腔血栓；其余6个病变可见厚纤维帽。1个病变可见新生血管和钙化，3个病变可见轻中度炎症。坏死核心出现在4/7的病变中，并且在唯一破坏的病变中与斑块破裂有关。在这组中风患者中，基底动脉粥样硬化病变相对良性。虽然需要更大样本量的证实，但新血管的相对缺乏提示可能具有独特的组织病理学特征。
There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. To define the nature of the basilar artery atherosclerotic lesions we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.
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影响因子：
8.3
作者：
SACCO, RL;KARGMAN, DE;ZAMANILLO, MC
通讯作者：
ZAMANILLO, MC
影响因子：
158.5
作者：
BARGER, AC;BEEUWKES, R;SILVERMAN, KJ
通讯作者：
SILVERMAN, KJ
影响因子：
64.8
作者：
Risau, W
通讯作者：
Risau, W
影响因子：
8.3
作者：
Mazighi, Mikael;Labreuche, Julien;Amarenco, Pierre
通讯作者：
Amarenco, Pierre
影响因子：
24
作者：
Falk, E
通讯作者：
Falk, E