Formation of 8-hydroxyguanine residues in DNA by X-irradiation.

Formation of 8-hydroxyguanine residues in DNA by X-irradiation.
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通过 X 射线照射在 DNA 中形成 8-羟基鸟嘌呤残基。

DOI:
10.20772/cancersci1959.75.12_1037
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发表时间:
1984
期刊:
Gan
影响因子:
--
通讯作者:
S. Nishimura
S. Nishimura
中科院分区:
--
文献类型:
--
作者:
H. Kasai;H. Tanooka;S. Nishimura

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在水溶液中X射线照射DNA后,发现了一种新的电离辐射诱导的DNA碱基损伤,即8-羟基鸟嘌呤的形成。这种修改的程度随X射线剂量的增加而线性增加,最高可达40 krad。当OH自由基清除剂,乙醇,被添加到DNA溶液中,羟基化几乎被完全抑制,这表明反应通过形成OH自由基进行。
A new type of ionizing radiation-induced DNA base damage, 8-hydroxyguanine formation, was found in DNA that had been irradiated by X-rays in aqueous solution. The extent of this modification linearly increased with increase in the X-ray dose up to 40 krad. When an OH radical scavenger, ethanol, was added to the DNA solution, the hydroxylation was inhibited almost completely, suggesting that the reaction proceeds via the formation of OH radicals.
DOI: 10.1073/pnas.78.2.1001
发表时间: 1981-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子: --
作者:
REPINE, JE;PFENNINGER, OW;PETTIJOHN, DE
通讯作者: PETTIJOHN, DE
电离辐射和氚嬗变都会导致细胞 DNA 中 5-羟甲基-2-脱氧尿苷的形成。
DOI: 10.1073/pnas.81.2.318
发表时间: 1984
影响因子: 11.1
作者:
Teebor,GW;Frenkel,K;Goldstein,MS
通讯作者: Goldstein,MS