Autonomic nervous system activity measured directly and QT interval variability in normal and pacing-induced tachycardia heart failure dogs.
Autonomic nervous system activity measured directly and QT interval variability in normal and pacing-induced tachycardia heart failure dogs.
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DOI：
10.1016/j.jacc.2009.06.008
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发表时间：
2009-08-25
影响因子：
24
通讯作者：
Chen, Peng-Sheng
中科院分区：
文献类型：
--
作者：
Piccirillo, Gianfranco;Magri, Damiano;Ogawa, Masahiro;Song, Juan;Chong, Voon J.;Han, Seongwook;Joung, Boyoung;Choi, Eue-Keun;Hwang, Samuel;Chen, Lan S.;Lin, Shien-Fong;Chen, Peng-Sheng
本研究旨在探讨起搏诱导的心动过速充血性心力衰竭（CHF）犬模型中交感神经和迷走神经活动与心脏复极之间的关系。QT变异指数（QTVI）是一种非侵入性的心脏复极离散度的标志物，是CHF期间猝死的危险因素之一。影响这一变量的因素包括心肌损伤和扩张型心肌病典型的自主神经系统活动。我们评估了自主神经系统的活动记录从植入的数据传输器，监测综合左星状神经节神经活动，综合迷走神经活动，和心电图。我们收集了36段记录在基线和36诱导CHF后。然后，我们任意确定记录片段包含低或高交感神经活动值，我们比较了校正的QT间期和QTVI在给定的交感神经活动条件下，在基线和诱导CHF后。在高交感神经活性亚组中，两个QT变量从基线到CHF增加（校正的QT间期，p < 0.01; QTVI，p < 0.05），而在低交感神经活性亚组中，它们保持不变。基线QTVI与综合迷走神经活动呈负相关（r2 = 0.16; β =-0.47; p < 0.05），而在CHF期间，QTVI与综合左星状神经节神经活动呈正相关（r2 = 0.32; β = 0.27，p < 0.01）。在CHF期间，交感神经激活与QT间期和QTVI的增加相关。由于这些变化随时间而变化，它们可能是心肌结构损伤和交感神经激活相结合的结果。相反，在正常情况下，交感神经激活和QT变量之间不存在关系。
This study sought to find out more about the relationship between sympathetic and vagal nerve activity and the cardiac repolarization in a canine model of pacing-induced tachycardia congestive heart failure (CHF). The QT variability index (QTVI), a noninvasive marker of temporal cardiac repolarization dispersion, is among the risk factors for sudden death during CHF. Among factors influencing this variable are the myocardial damage and the autonomic nervous system activity typical of dilated cardiomyopathy. We assessed autonomic nervous system activity recorded from an implanted data transmitter that monitored integrated left stellate-ganglion nervous activity, integrated vagus nerve activity, and electrocardiogram. We collected 36 segments recorded at baseline and 36 after induced CHF. We then arbitrarily identified recording segments as containing low or high sympathetic activity values, and we compared corrected QT intervals and the QTVI under a given sympathetic activity condition at baseline and after inducing CHF. In the high sympathetic activity subgroup, both QT variables increased from baseline to CHF (corrected QT intervals, p < 0.01; QTVI, p < 0.05) whereas in the low sympathetic activity subgroup they remained unchanged. The baseline QTVI correlated inversely with integrated vagus nerve activity (r2 = 0.16; β = −0.47; p < 0.05) whereas, during CHF, the QTVI correlated directly with integrated left stellate-ganglion nervous activity (r2 = 0.32; β = 0.27, p < 0.01). During CHF, sympathetic activation is associated with an increase in the QT interval and QTVI. Because these changes vary over time, they could result from myocardial structural damage and sympathetic activation combined. Conversely, under normal conditions, no relationship exists between sympathetic activation and the QT variables.
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影响因子：
7.8
作者：
Piccirillo, Gianfranco;Magnanti, Marzia;Magri, Damiano
通讯作者：
Magri, Damiano
影响因子：
37.8
作者：
Pitzalis, MV;Mastropasqua, F;Rizzon, P
通讯作者：
Rizzon, P
影响因子：
24
作者：
Haigney, MC;Zareba, W;Moss, AJ
通讯作者：
Moss, AJ
影响因子：
24
作者：
Ogawa, Masahiro;Zhou, Shengmei;Chen, Peng-Sheng
通讯作者：
Chen, Peng-Sheng
影响因子：
37.8
作者：
Jost, N;Virág, L;Varró, A
通讯作者：
Varró, A