Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.

Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.
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DOI:
10.1126/science.aba5216
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发表时间:
2020-05-15
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Schumer M
Schumer M
中科院分区:
其他
文献类型:
--
作者:
Powell DL;García-Olazábal M;Keegan M;Reilly P;Du K;Díaz-Loyo AP;Banerjee S;Blakkan D;Reich D;Andolfatto P;Rosenthal GG;Schartl M;Schumer M

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种群之间建立的生殖障碍可以促进新物种的进化。这一过程的遗传框架假定,基因之间的“不相容”相互作用可以进化,导致杂交后代的生存或繁殖减少。然而,在确定导致杂种不亲和性的单个基因方面进展缓慢。我们使用了一种组合的方法来绘制基因,驱动发展的不相容性,导致黑色素瘤的剑尾鱼杂交。与这种不相容性有关的基因之一也会导致远亲物种之间的杂交瘤。此外,这种黑色素瘤降低了野生动物的生存率,可能是因为鳍的逐渐退化。这项工作确定了脊椎动物杂交不相容性的基因,并提供了一个一瞥这些基因在自然杂交种群的行动。
The establishment of reproductive barriers between populations can fuel the evolution of new species. A genetic framework for this process posits that “incompatible” interactions between genes can evolve that result in reduced survival or reproduction in hybrids. However, progress has been slow in identifying individual genes that underlie hybrid incompatibilities. We used a combination of approaches to map the genes that drive the development of an incompatibility that causes melanoma in swordtail fish hybrids. One of the genes involved in this incompatibility also causes melanoma in hybrids between distantly related species. Moreover, this melanoma reduces survival in the wild, likely because of progressive degradation of the fin. This work identifies genes underlying a vertebrate hybrid incompatibility and provides a glimpse into the action of these genes in natural hybrid populations.
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发表时间: 2011-01-01
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