Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know.
Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know.
复制标题
强迫症和相关疾病的基因组学：临床医生需要了解的内容。
DOI：
10.1016/j.psc.2022.11.003
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发表时间：
2023-03
影响因子：
1.7
通讯作者：
Crowley, James J.
中科院分区：
文献类型：
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作者：
Crowley, James J.
关键词：
大量的遗传流行病学证据表明，遗传在强迫症（OCD）及其所有相关疾病（震颤狂、皮肤采摘障碍、囤积障碍和身体畸形障碍）的易感性中起着重要作用。几个大规模的，使用现代基因组学方法的合作努力开始揭示这些特征的遗传结构，并确定长期寻找的风险基因。在这篇文章中，我们总结了目前的强迫症和相关疾病的基因组知识，并解释了如何将这些信息传达给患者及其家属。随着时间的推移，这些基因组发现中的一些可能具有临床意义，药物遗传学可能是第一个例子。文章最后讨论了强迫症和相关疾病的基因组发现如何为我们了解疾病病因提供信息，并为治疗开发提供新的靶点。本手稿在Elsevier用户许可证https：//www下提供。爱思唯尔。com/open-access/userlicense/1.0/
A wealth of genetic epidemiological evidence has shown that genetics plays a major role in susceptibility to obsessive-compulsive disorder (OCD) and all of its related disorders (trichotillomania, skin picking disorder, hoarding disorder and body dysmorphic disorder). Several large-scale, collaborative efforts using modern genomic methods are beginning to reveal the genetic architecture of these traits and identify long-sought risk genes. In this article, we summarize current OCD and related disorder genomic knowledge and explain how to communicate this information to patients and their families. In time, some of these genomic findings are likely to have clinical implications, with pharmacogenetics perhaps representing the first example. The article concludes with a discussion of how genomic discovery in OCD and related disorders can inform our understanding of disease etiology and provide novel targets for therapeutic development.© 2022 published by Elsevier. This manuscript is made available under the Elsevier user license https://www. elsevier. com/open-access/userlicense/1.0/
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影响因子：
11
作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
通讯作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
影响因子：
6.8
作者：
Burton CL;Park LS;Corfield EC;Forget-Dubois N;Dupuis A;Sinopoli VM;Shan J;Goodale T;Shaheen SM;Crosbie J;Schachar RJ;Arnold PD
通讯作者：
Arnold PD
影响因子：
4.8
作者：
Greden, John F.;Parikh, Sagar V.;Dechairo, Bryan
通讯作者：
Dechairo, Bryan
影响因子：
4.1
作者：
FROST, RO;GROSS, RC
通讯作者：
GROSS, RC
影响因子：
30.8
作者：
通讯作者：
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