Heritability of obsessive-compulsive trait dimensions in youth from the general population.
Heritability of obsessive-compulsive trait dimensions in youth from the general population.
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DOI：
10.1038/s41398-018-0249-9
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发表时间：
2018-09-18
影响因子：
6.8
通讯作者：
Arnold PD
中科院分区：
文献类型：
--
作者：
Burton CL;Park LS;Corfield EC;Forget-Dubois N;Dupuis A;Sinopoli VM;Shan J;Goodale T;Shaheen SM;Crosbie J;Schachar RJ;Arnold PD
强迫症（OCD）是一种遗传性的儿童期发病的精神疾病，可能代表了普通人群中普遍存在的强迫症（OC）的极端特征。我们报告了多伦多强迫症量表 (TOCS) 的遗传力，这是一项旨在评估青少年所有 OC 特征的新测量方法。我们还研究了 TOCS 的维度性质以及遗传效应在维度之间独特或共享的程度。使用 TOCS 在科学博物馆对 16,718 名青少年（6-18 岁）进行了 OC 特征测量。我们进行了因子分析来确定 OC 特质维度。我们使用单变量和多变量双胞胎模型来估计双胞胎子集（220 对）中 OC 特征维度的遗传力。确定了六个 OC 维度：清洁/污染、对称/有序、沉思、迷信、计数/检查和囤积。 TOCS 总分 (74%) 和每个 OC 维度都是可遗传的 (30-77%)。囤积与其他 OC 维度的相关性并不高，但确实具有共同的遗传效应。共享遗传学解释了维度之间的大部分共享方差，而独特的环境则解释了维度特定方差的大部分。囤积症是一个例外，它有相当多独特的遗传因素。潜在特征并不能解释维度之间的共同方差。总之，OC 特征和个体 OC 维度是可遗传的，尽管共享和维度特异性病因因素的程度因维度而异。 TOCS 可能为青少年 OC 特征的遗传研究提供信息。 OC性状的遗传学研究应同时考虑OC维度和总性状得分。
Obsessive–compulsive disorder (OCD) is a heritable childhood-onset psychiatric disorder that may represent the extreme of obsessive–compulsive (OC) traits that are widespread in the general population. We report the heritability of the Toronto Obsessive–Compulsive Scale (TOCS), a new measure designed to assess the complete range of OC traits in youth. We also examined the dimensional nature of the TOCS and the degree to which genetic effects are unique or shared between dimensions. OC traits were measured using the TOCS in 16,718 youth (6–18 years) at a science museum. We conducted a factor analysis to identify OC trait dimensions. We used univariate and multivariate twin models to estimate the heritability of OC trait dimensions in a subset of twins (220 pairs). Six OC dimensions were identified: Cleaning/Contamination, Symmetry/Ordering, Rumination, Superstition, Counting/Checking, and Hoarding. The TOCS total score (74%) and each OC dimension was heritable (30–77%). Hoarding was not highly correlated with other OC dimensions, but did share genetic effects. Shared genetics accounted for most of the shared variance among dimensions, whereas unique environment accounted for the majority of dimension-specific variance. One exception was Hoarding, which had considerable unique genetic factors. A latent trait did not account for the shared variance between dimensions. In conclusion, OC traits and individual OC dimensions were heritable, although the degree of shared and dimension-specific etiological factors varied by dimension. The TOCS may be informative for genetic research of OC traits in youth. Genetic research of OC traits should consider both OC dimension and total trait scores.
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影响因子：
11
作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
通讯作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
DOI：
10.1176/appi.ajp.2008.08020320
发表时间：
2008-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Bloch MH;Landeros-Weisenberger A;Rosario MC;Pittenger C;Leckman JF
通讯作者：
Leckman JF
影响因子：
3
作者：
Boker S;Neale M;Maes H;Wilde M;Spiegel M;Brick T;Spies J;Estabrook R;Kenny S;Bates T;Mehta P;Fox J
通讯作者：
Fox J
影响因子：
--
作者：
Hudziak, JJ;van Beijsterveldt, CEM;Boomsma, DI
通讯作者：
Boomsma, DI
DOI：
10.1111/j.1469-7610.2005.01465.x
发表时间：
2006-02-01
影响因子：
7.6
作者：
Hudziak, JJ;Althoff, RR;Todd, RD
通讯作者：
Todd, RD