Dietary fish oil increases fat absorption and fecal bile acid content without altering bile acid synthesis in 20-d-old weanling rats following massive ileocecal resection.
Dietary fish oil increases fat absorption and fecal bile acid content without altering bile acid synthesis in 20-d-old weanling rats following massive ileocecal resection.
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DOI：
10.1038/pr.2012.41
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发表时间：
2012-07
影响因子：
3.6
通讯作者：
Dawson, Paul A.
中科院分区：
文献类型：
--
作者：
Yang, Qing;Lan, Tian;Chen, Yuegang;Dawson, Paul A.
据报道，鱼油（FO）可降低回盲部切除术（ICR）后短肠综合征（SBS）断奶大鼠模型的粪便脂肪排泄，并诱导成年大鼠胆汁酸（BA）分泌和合成的变化。我们假设，与玉米油（CO）相比，膳食FO增加了断奶SBS大鼠的肠道脂肪吸收，部分原因是肝脏BA合成和管腔BA浓度增加。在进行ICR后，20日龄的大鼠自由喂食7天的CO或FO饮食含有5%的蔗糖聚山嵛酸酯（SPB），膳食脂肪吸收的标志物。测定粪便脂肪酸、粪便和肠腔BA、肝脏胆固醇7α-羟化酶（Cyp 7 α1）和甾醇12α-羟化酶（Cyp 8 β1）mRNA表达以及血清7α-羟基-4-异戊烯-3-1（7αC4）水平。与CO-ICR大鼠相比，FO-ICR大鼠对总脂肪和大多数脂肪酸的肠道吸收更高。尽管FO-ICR大鼠每克干粪便中的BA含量增加，但各组间残留空肠中的BA含量、BA生物合成酶Cyp 7 α1和Cyp 8 β1的肝脏mRNA表达以及BA合成标记物7αC4均无差异。在断乳SBS大鼠中，膳食FO增加膳食脂肪吸收而不增加肝脏BA合成。
Dietary fish oil (FO) was reported to lower fecal fat excretion in a weanling rat model of short bowel syndrome (SBS) after ileocecal resection (ICR), and to induce changes in secretion and synthesis of bile acid (BA) in adults. We hypothesized that dietary FO, as compared with corn oil (CO), increases intestinal fat absorption in weanling SBS rats in part due to increased hepatic BA synthesis and luminal BA concentrations. After undergoing ICR, 20-d-old rats were fed ad lib for 7 d with a CO or FO diet containing 5% sucrose polybehenate (SPB), a marker for dietary fat absorption. Fecal fatty acid, fecal and intestine luminal BA, liver mRNA expressions of cholesterol 7α-hydroxylase (Cyp7α1) and sterol-12α-hydroxylase (Cyp8β1), and serum 7α-hydroxy-4-cholesten-3-1 (7αC4) levels were determined. As compared with CO-ICR rats, FO-ICR rats had higher intestinal absorption of total fat and most individual fatty acids. Although the BA content per gram of dry stool was increased in FO-ICR rats, there were no differences between groups for the BA content in remnant jejunum, liver mRNA expression of BA biosynthetic enzymes, Cyp7α1 and Cyp8β1, or serum 7αC4, a marker for BA synthesis. Dietary FO increases dietary fat absorption without increasing hepatic BA synthesis in weanling SBS rats.
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影响因子：
4.8
作者：
Dawson, PA;Haywood, J;Parks, JS
通讯作者：
Parks, JS
DOI：
10.1097/mpg.0b013e3181c2c2af
发表时间：
2010-01-01
影响因子：
2.9
作者：
Yang, Qing;Kock, Nancy D.
通讯作者：
Kock, Nancy D.
影响因子：
1.8
作者：
Sukhotnik, I;Mor-Vaknin, N;Harmon, CM
通讯作者：
Harmon, CM
DOI：
10.1152/ajpgi.00017.2008
发表时间：
2008-04-01
影响因子：
4.5
作者：
Wooton-Kee, Clavia Ruth;Cohen, David E.;Vore, Mary
通讯作者：
Vore, Mary
影响因子：
3.5
作者：
Bérard, AM;Dumon, MF;Darmon, M
通讯作者：
Darmon, M