Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates.
Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates.
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克服记忆T细胞反应，以诱导非人类灵长类动物的延迟公差。
DOI：
10.1111/j.1600-6143.2011.03795.x
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Kawai T
中科院分区：
文献类型：
--
作者：
Yamada Y;Boskovic S;Aoyama A;Murakami T;Putheti P;Smith RN;Ochiai T;Nadazdin O;Koyama I;Boenisch O;Najafian N;Bhasin MK;Colvin RB;Madsen JC;Strom TB;Sachs DH;Benichou G;Cosimi AB;Kawai T
The presence of alloreactive memory T cells is a major barrier for induction of tolerance in primates. In theory, delaying conditioning for tolerance induction until after organ transplantation could further decrease the efficacy of the regimen, since pre-existing alloreactive memory T cells might be stimulated by the transplanted organ. Here, we show that such “delayed tolerance” can be induced in nonhuman primates through the mixed chimerism approach, if specific modifications to overcome/avoid donor-specific memory T cell responses are provided. These modifications include adequate depletion of CD8+ memory T cells and timing of donor bone marrow administration to minimize levels of pro-inflammatory cytokines. Using this modified approach, mixed chimerism was induced successfully in 11 of 13 recipients of previously placed renal allografts and long-term survival without immunosuppression could be achieved in at least 6 of these 11 animals.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1084/jem.20060376
发表时间：
2006-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.0800997
发表时间：
2009-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bucks CM;Norton JA;Boesteanu AC;Mueller YM;Katsikis PD
通讯作者：
Katsikis PD
DOI：
10.1084/jem.171.3.801
发表时间：
1990-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mackay CR;Marston WL;Dudler L
通讯作者：
Dudler L
影响因子：
6.2
作者：
Kirk, AD;Mannon, RB;Hale, DA
通讯作者：
Hale, DA