Brain dendritic cells: biology and pathology.
Brain dendritic cells: biology and pathology.
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DOI：
10.1007/s00401-012-1018-0
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发表时间：
2012-11
影响因子：
12.7
通讯作者：
Bulloch K
中科院分区：
文献类型：
--
作者：
D'Agostino PM;Gottfried-Blackmore A;Anandasabapathy N;Bulloch K
树突状细胞（DC）是免疫系统的专职抗原呈递细胞。在其静止和成熟形式中，DC对自身抗原的呈递导致耐受性;而在病原体相关分子模式刺激后，成熟DC的抗原呈递导致抗原特异性免疫的发生。DC已经在哺乳动物的许多主要器官（例如皮肤、心脏、肺、肠和脾）中被发现，而在没有神经炎症的情况下，脑长期被认为缺乏DC。因此，小胶质细胞，大脑的常驻免疫细胞，已被指控与许多功能属性通常归因于DC。最近的证据已经挑战了DC在脑免疫监视中要么不存在要么最小的参与者的概念。这篇综述将讨论最近的文献研究DC参与在年轻和老年人的稳态大脑。我们还将研究DC的贡献，在各种形式的神经炎症引起的神经退行性自身免疫性疾病，损伤和中枢神经系统感染。这篇综述还涉及在病毒感染期间中枢神经系统和外周免疫区室之间的DC贩运，新的分子技术，可用于提高我们目前对脑DC个体发育的理解，以及DC在CNS内的一些潜在治疗用途。
Dendritic cells (DC) are the professional antigen-presenting cells of the immune system. In their quiescent and mature form, the presentation of self-antigens by DC leads to tolerance; whereas, antigen presentation by mature DC, after stimulation by pathogen-associated molecular patterns, leads to the onset of antigen-specific immunity. DC have been found in many of the major organs in mammals (e.g. skin, heart, lungs, intestines and spleen), while the brain has long been considered devoid of DC in the absence of neuroinflammation. Consequently, microglia, the resident immune cell of the brain, have been charged with many functional attributes commonly ascribed to DC. Recent evidence has challenged the notion that DC are either absent or minimal players in brain immune surveillance. This review will discuss the recent literature examining DC involvement within both the young and aged steady-state brain. We will also examine DC contributions during various forms of neuroinflammation resulting from neurodegenerative autoimmune disease, injury, and CNS infections. This review also touches upon DC trafficking between the central nervous system and peripheral immune compartments during viral infections, the new molecular technologies that could be employed to enhance our current understanding of brain DC ontogeny, and some potential therapeutic uses of DC within the CNS.
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影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
影响因子：
2.5
作者：
Bulloch, Karen;Miller, Melinda M.;McEwen, Bruce S.
通讯作者：
McEwen, Bruce S.
影响因子：
5.3
作者：
Bechmann, I;Kwidzinski, E;Nitsch, R
通讯作者：
Nitsch, R
影响因子：
4.4
作者：
Ciavarra, Richard P.;Stephens, Amber;Steel, Christina
通讯作者：
Steel, Christina
影响因子：
4.4
作者：
Brehin, Anne-Claire;Mouries, Juliette;Couderc, Therese
通讯作者：
Couderc, Therese