Sodium-potassium ATPase in deoxycorticosterone-salt hypertension: opposing effects of sodium load and mineralocorticoids.
Sodium-potassium ATPase in deoxycorticosterone-salt hypertension: opposing effects of sodium load and mineralocorticoids.
复制标题
脱氧皮质酮盐高血压中的钠钾 ATP 酶：钠负荷和盐皮质激素的相反作用。
作者：
N. Stern;F. Beck;N. Vlachakis;P. Eggena;J. Sowers
先前在脱氧皮质酮（DOC）-盐（DS）高血压模型中对钠-钾泵的研究产生了相反的结果，一些研究者报告泵活性增加，另一些研究者发现泵活性降低。为了测试钠超载和盐皮质激素活性的单独作用导致DS大鼠中的净泵活性的可能性，我们将DS大鼠中的Na+-K+-ATP酶泵与这些潜在决定因素不一致的其他实验模型中的Na+-K+-ATP酶泵进行了比较。肾皮质和心肌ATP酶活性测定对照组大鼠;肾上腺切除盐水充盈大鼠;肾上腺切除醛固酮或地塞米松充盈大鼠;单侧肾切除，盐水饮用大鼠;和单侧肾切除，盐水饮用，DOC和盐治疗的大鼠。DOC和盐处理的大鼠有较高的（P小于0.001）血压和较低的（P小于0.05）血清钾水平比对照组大鼠。肾皮质和心肌ATP酶活性显着下降（P <0.01）肾上腺切除，盐水充满大鼠，但可以至少部分恢复醛固酮或地塞米松治疗。单肾切除，盐水饮用大鼠肾皮质和心肌ATP酶活性降低（P <0.01）与对照组相比。在单侧肾切除，盐水饮水大鼠DOC，肾皮质和心肌ATP酶活性与对照值没有差异。这项研究的结果表明，钠超载相关的抑制和DOC介导的刺激的相反作用，在DOC和盐处理的大鼠的Na+-K+-ATP酶泵调制。
Previous studies of the sodium-potassium pump in the deoxycorticosterone (DOC)-salt (DS) model of hypertension yielded contrasting results, some investigators reporting increased and others finding decreased pump activity. To test the possibility that the net pump activity in the DS rats results from separate effects of sodium overload and mineralocorticoid activity, we compared the Na+-K+-ATPase pump in DS rats with that in other experimental models in which these potential determinants do not coincide. Renocortical and myocardial ATPase activities were measured in control rats; adrenalectomized-saline-repleted rats; adrenalectomized aldosterone- or dexamethasone-repleted rats; uninephrectomized, saline-drinking rats; and uninephrectomized, saline-drinking, DOC- and salt-treated rats. DOC- and salt-treated rats had higher (P less than 0.001) blood pressures and lower (P less than 0.05) serum potassium levels than control rats. Renocortical and myocardial ATPase activities were considerably (P less than 0.01) decreased in adrenalectomized, saline-repleted rats, but could be at least partially restituted by either aldosterone or dexamethasone therapy. Uninephrectomized, saline-drinking rats had reduced (P less than 0.01) renocortical and myocardial ATPase activities compared with control rats. In uninephrectomized, saline-drinking rats treated with DOC, renocortical and myocardial ATPase activities were not different from control values. The results of this study suggest that the Na+-K+-ATPase pump in DOC- and salt-treated rats is modulated by the opposing effects of sodium overload-associated suppression and DOC-mediated stimulation.
AV3V 病变对 DOCA 盐高血压和血管钠泵活性发展的影响。
DOI：
10.1161/01.hyp.4.5.575
发表时间：
1982
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
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作者：
Songu-Mize,E;Bealer,SL;Caldwell,RW
通讯作者：
Caldwell,RW