Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.
Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.
复制标题
DOI：
10.1111/bju.12720
复制
发表时间：
2014-11
影响因子：
4.5
通讯作者：
Freedland SJ
中科院分区：
文献类型：
--
作者：
Allott EH;Howard LE;Cooperberg MR;Kane CJ;Aronson WJ;Terris MK;Amling CL;Freedland SJ
目的探讨术前未使用他汀类药物的前列腺癌根治术患者术后应用他汀类药物对生化复发(BCR)的影响。·我们在共享的平等访问区域肿瘤医院(SEARCH)数据库中对1146名RP患者进行了回顾性分析。·使用多变量COX比例风险分析来检验术后使用他汀类药物和不使用他汀类药物的患者发生BCR的风险差异。·考虑到在随访期间他汀类药物的开始日期和持续时间不同，术后他汀类药物的使用被视为一个时间依赖变量。·在二次分析中，根据种族对模型进行分层，以检查黑人和非黑人男性术后他汀类药物使用与BCR的关系。·在调整了临床和病理特征后，术后应用他汀类药物显著降低了36%的BCR风险(HR0.64；95%CI0.47-0.87；p=0.004)。·在调整了术前血清胆固醇水平后，术后他汀类药物的使用仍然与BCR风险的降低有关。·在二次分析中，在按种族分层后，这种保护性关联在非黑人男性中显著(HR0.49；95%CI0.32-0.75；p=0.001)，但在黑人男性中没有(HR0.82；95%CI0.53-1.28；p=0.384)。·在这组接受RP的男性回溯性队列中，术后他汀类药物的使用与降低BCR风险显著相关。·术后他汀类药物的使用与BCR之间的关联是否因种族而异，还需要进一步研究。·鉴于这些发现，再加上其他研究表明，他汀类药物可能会降低晚期PC的风险，有必要进行随机对照试验，以正式测试他汀类药物减缓PC进展的假设。
• To investigate the effect of postoperative statin use on biochemical recurrence (BCR) in PC patients treated with radical prostatectomy (RP) who never used statins before surgery. • We conducted a retrospective analysis of 1,146 RP patients within the Shared Equal Access Regional Cancer Hospital (SEARCH) database. • Multivariable Cox proportional hazards analyses were used to examine differences in risk of BCR between postoperative statin users versus nonusers. • To account for varying start dates and duration of statin use during follow-up, postoperative statin use was treated as a time-dependent variable. • In secondary analysis, models were stratified by race to examine the association of postoperative statin use with BCR among black and non-black men. • After adjusting for clinical and pathological characteristics, postoperative statin use was significantly associated with 36% reduced risk of BCR (HR 0.64; 95%CI 0.47-0.87; p=0.004). • Postoperative statin use remained associated with reduced risk of BCR after adjusting for preoperative serum cholesterol levels. • In secondary analysis, following stratification by race, this protective association was significant in non-black (HR 0.49; 95%CI 0.32-0.75; p=0.001) but not black men (HR 0.82; 95%CI 0.53-1.28; p=0.384). • In this retrospective cohort of men undergoing RP, postoperative statin use was significantly associated with reduced risk of BCR. • Whether the association between postoperative statin use and BCR differs by race requires further study. • Given these findings, coupled with other studies suggesting that statins may reduce risk of advanced PC, randomized controlled trials are warranted to formally test the hypothesis that statins slow PC progression.
登录
查看更多内容
影响因子：
3.7
作者：
Mostaghel EA;Solomon KR;Pelton K;Freeman MR;Montgomery RB
通讯作者：
Montgomery RB
影响因子：
4
作者：
Pelton, Kristine;Freeman, Michael R.;Solomon, Keith R.
通讯作者：
Solomon, Keith R.
影响因子：
3.7
作者：
Bansal D;Undela K;D'Cruz S;Schifano F
通讯作者：
Schifano F
影响因子：
4.8
作者：
Lewey, Jennifer;Shrank, William H.;Choudhry, Niteesh K.
通讯作者：
Choudhry, Niteesh K.
影响因子：
23.4
作者：
Masko, Elizabeth M.;Allott, Emma H.;Freedland, Stephen J.
通讯作者：
Freedland, Stephen J.