The relationship between nutrition and prostate cancer: is more always better?
The relationship between nutrition and prostate cancer: is more always better?
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DOI：
10.1016/j.eururo.2012.11.012
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发表时间：
2013-05
期刊：
影响因子：
23.4
通讯作者：
Freedland, Stephen J.
中科院分区：
文献类型：
--
作者：
Masko, Elizabeth M.;Allott, Emma H.;Freedland, Stephen J.
前列腺癌（PCa）仍然是世界上诊断最多的恶性肿瘤之一，这与男性多吃所谓西方饮食的地区有关。因此，人们对了解生活方式和饮食在前列腺癌发病率和进展中的作用非常感兴趣。提供关于膳食宏量和微量营养素与前列腺癌发病率和进展的已发表文献的总结。使用PubMed数据库检索2012年6月或更早发表的关于饮食和PCa的所有研究。在可能的情况下，优先考虑主要文献和荟萃分析，而不是其他综述文章。对碳水化合物、蛋白质、脂肪和胆固醇、蔬菜、维生素和矿物质、植物化学物质等7种膳食成分进行了综述。目前将这些营养素与PCa联系起来的文献最多是有限的，但已发表数据的趋势表明，摄入碳水化合物、饱和脂肪和ω-6脂肪以及某些维生素补充剂可能会增加PCa的风险和进展。相反，食用许多植物化学物质和ω-3脂肪酸似乎可以减缓疾病的风险和进展。所有其他营养物质似乎都没有效果，或者数据不确定。简要总结了饮食干预在前列腺癌预防、治疗和生存方面的临床意义。由于调查饮食和前列腺癌的已发表研究的数量和异质性，很难确定哪些营养成分构成了对前列腺癌一级和二级预防的完美饮食。由于饮食是由多种宏量和微量营养素组成的，进一步的前瞻性研究是有必要的，特别是那些调查全食物而不是单一营养成分之间关系的研究。
Prostate cancer (PCa) remains one of the most diagnosed malignancies in the world, correlating with regions where men consume more of a so-called Western-style diet. As such, there is much interest in understanding the role of lifestyle and diet on the incidence and progression of PCa. To provide a summary of published literature with regard to dietary macro- and micronutrients and PCa incidence and progression. A literature search was completed using the PubMed database for all studies published on diet and PCa in June 2012 or earlier. Primary literature and meta-analyses were given preference over other review articles when possible. The literature was reviewed on seven dietary components: carbohydrates, protein, fat and cholesterol, vegetables, vitamins and minerals, and phytochemicals. Current literature linking these nutrients to PCa is limited at best, but trends in the published data suggest consumption of carbohydrates, saturated and ω-6 fats, and certain vitamin supplements may promote PCa risk and progression. Conversely, consumption of many plant phytochemicals and ω-3 fatty acids seem to slow the risk and progression of the disease. All other nutrients seem to have no effect or data are inconclusive. A brief summary about the clinical implications of dietary interventions with respect to PCa prevention, treatment, and survivorship is provided. Due to the number and heterogeneity of published studies investigating diet and PCa, it is difficult to determine what nutrients make up the perfect diet for the primary and secondary prevention of PCa. Because diets are made of multiple macro- and micronutrients, further prospective studies are warranted, particularly those investigating the relationship between whole foods instead of a single nutritional component.
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影响因子：
6.2
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
2.1
作者：
Daubenmier, JJ;Weidner, G;Ornish, D
通讯作者：
Ornish, D
DOI：
10.1016/j.juro.2009.08.104
发表时间：
2010-01
期刊：
The Journal of urology
影响因子：
--
作者：
Aronson WJ;Barnard RJ;Freedland SJ;Henning S;Elashoff D;Jardack PM;Cohen P;Heber D;Kobayashi N
通讯作者：
Kobayashi N
影响因子：
50.5
作者：
Bidoli, E;Talamini, R;La Vecchia, C
通讯作者：
La Vecchia, C
影响因子：
10.3
作者：
Ahn, Jiyoung;Peters, Ulrike;Hayes, Richard B.
通讯作者：
Hayes, Richard B.