The Separation and Identification of Synthetic Cathinones by Portable Low Microflow Liquid Chromatography with Dual Capillary Columns in Series and Dual Wavelength Ultraviolet Detection.
The Separation and Identification of Synthetic Cathinones by Portable Low Microflow Liquid Chromatography with Dual Capillary Columns in Series and Dual Wavelength Ultraviolet Detection.
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双毛细管柱串联和双波长紫外检测的便携式低微流液相色谱法分离和鉴定合成卡西酮。
DOI：
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发表时间：
2020
影响因子：
3.1
通讯作者：
I. Lurie
中科院分区：
文献类型：
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作者：
M. C. May;David C Pavone;I. Lurie
这项研究确定了便携式液相色谱仪的可行性，该色谱仪以低μL/分钟的流量运行，用于分析远程站点以及实验室环境中缉获的药物。使用串联双毛细管柱（C8 和联苯）筛选合成卡西酮，并在 255 nm 和 275 nm 处进行柱上紫外检测。使用串联的两根色谱柱的相对保留时间及其峰面积吸光度比来确定是否可以在这些条件下唯一地鉴定所研究的 16 种合成卡西酮。根据这些参数可以区分所有分析物。使用合成卡西酮的代表性混合物来确定该方法的重复性、线性和检测限。这种具有成本效益的绿色仪器有可能满足检获药物分析的最低国际准则。本文受版权保护。版权所有。
This study ascertained the viability of a portable liquid chromatograph, operating at low μL/min flow, for the analysis of seized drugs at remote sites as well as in laboratory settings. Synthetic cathinones were screened using dual capillary columns in series, C8 and biphenyl, with on-column ultraviolet detection at 255 nm and 275 nm. The relative retention times of the two columns in series and their peak area absorbance ratio were used to determine if the 16 synthetic cathinones investigated could be uniquely identified in these conditions. Based on these parameters all of the analytes could be distinguished. Representative mixtures of synthetic cathinones were used to determine the repeatability, linearity, and limits of detection of the method. This cost effective and green instrumentation has the potential to satisfy minimum international guidelines for the analysis of seized drugs. This article is protected by copyright. All rights reserved.
影响因子：
6.1
作者：
German, Christopher L.;Fleckenstein, Annette E.;Hanson, Glen R.
通讯作者：
Hanson, Glen R.