Individual differences in biological stress responses moderate the contribution of early peer victimization to subsequent depressive symptoms.
Individual differences in biological stress responses moderate the contribution of early peer victimization to subsequent depressive symptoms.
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DOI：
10.1007/s00213-010-1879-7
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发表时间：
2011-03
影响因子：
3.4
通讯作者：
Granger, Douglas A.
中科院分区：
文献类型：
--
作者：
Rudolph, Karen D.;Troop-Gordon, Wendy;Granger, Douglas A.
一些早期遭受同伴伤害的孩子会变得抑郁，而另一些孩子则会恢复过来。了解个体对早期逆境（如受害）反应的差异，对于开发全面的理论模型和有效的干预措施至关重要。本研究考察了生物应激反应（即，下丘脑-垂体-肾上腺轴和自主神经系统的激活）的个体差异是否在一年内减缓同伴受害对抑郁症状的贡献。儿童（N = 132； M年龄= 9.46岁，SD = 0.33）完成了同伴受害和抑郁症状的测量，并评估了他们对一个不熟悉的同伴涉及两种利益冲突情境的基于实验室的社会挑战任务的反思反应（即持续思考与任务相关的消极情绪和经历）。在参与任务之前和之后收集儿童的唾液，随后检测皮质醇和α淀粉酶[sAA]。受害与预期任务中测量的皮质醇水平相互作用，以预测一年后与任务相关的反刍和抑郁症状，并根据初始症状进行调整。具体来说，受害是反刍和抑郁症状的一个风险因素，在预期皮质醇升高但不抑制的儿童中；然而，提高预期皮质醇对低受害儿童的反刍和抑郁症状有保护作用。受害也预示了在整个任务中sAA反应性高的女孩随后的抑郁症状。本研究通过暗示生物应激反应的个体差异作为早期逆境对心理健康影响敏感性的一个决定因素，推进了当代理论和研究。
Some children who are exposed to early peer victimization become depressed, whereas others are resilient. Understanding individual differences in responses to early adversity, such as victimization, is critical for developing both comprehensive theoretical models and effective interventions. This study examined whether individual differences in biological stress responses (i.e., activation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system) moderated the contribution of peer victimization to depressive symptoms across a one-year period. Children (N = 132; M age = 9.46 years, SD = .33) completed measures of peer victimization and depressive symptoms, and rated their ruminative responses (i.e., persistent thoughts about negative task-related emotion and experiences) to a laboratory-based social challenge task involving two conflict-of-interests situations with an unfamiliar peer. Children’s saliva was collected prior to, and following, participation in the task, and was later assayed for cortisol and alpha amylase [sAA]. Victimization interacted with levels of cortisol measured in anticipation of the task to predict task-related rumination and depressive symptoms one year later, adjusting for initial symptoms. Specifically, victimization served as a risk factor for rumination and depressive symptoms in children with heightened but not dampened anticipatory cortisol; yet, heightened anticipatory cortisol was protective against rumination and depressive symptoms in low-victimized children. Victimization also predicted subsequent depressive symptoms in girls with high sAA reactivity across the task. This study advances contemporary theory and research by implicating individual variation in biological stress responses as one determinant of sensitivity to the mental health effects of early adversity.
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影响因子：
4
作者：
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通讯作者：
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