Plant-Specific Domains and Fragmented Sequences Imply Non-Canonical Functions in Plant Aminoacyl-tRNA Synthetases.
Plant-Specific Domains and Fragmented Sequences Imply Non-Canonical Functions in Plant Aminoacyl-tRNA Synthetases.
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DOI：
10.3390/genes11091056
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发表时间：
2020-09-07
期刊：
影响因子：
3.5
通讯作者：
Kushiro T
中科院分区：
文献类型：
--
作者：
Saga Y;Kawashima M;Sakai S;Yamazaki K;Kaneko M;Takahashi M;Sato N;Toyoda Y;Takase S;Nakano T;Kawakami N;Kushiro T
Aminoacyl-tRNA synthetases (aaRSs) play essential roles in protein translation. In addition, numerous aaRSs (mostly in vertebrates) have also been discovered to possess a range of non-canonical functions. Very few studies have been conducted to elucidate or characterize non-canonical functions of plant aaRSs. A genome-wide search for aaRS genes in Arabidopsis thaliana revealed a total of 59 aaRS genes. Among them, asparaginyl-tRNA synthetase (AsnRS) was found to possess a WHEP domain inserted into the catalytic domain in a plant-specific manner. This insertion was observed only in the cytosolic isoform. In addition, a long stretch of sequence that exhibited weak homology with histidine ammonia lyase (HAL) was found at the N-terminus of histidyl-tRNA synthetase (HisRS). This HAL-like domain has only been seen in plant HisRS, and only in cytosolic isoforms. Additionally, a number of genes lacking minor or major portions of the full-length aaRS sequence were found. These genes encode 14 aaRS fragments that lack key active site sequences and are likely catalytically null. These identified genes that encode plant-specific additional domains or aaRS fragment sequences are candidates for aaRSs possessing non-canonical functions.
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影响因子：
64.8
作者：
Sajish, Mathew;Schimmel, Paul
通讯作者：
Schimmel, Paul
影响因子：
4.8
作者：
Champagne, KS;Sissler, M;Francklyn, SS
通讯作者：
Francklyn, SS
DOI：
10.1073/pnas.96.16.8985
发表时间：
1999-08-03
影响因子：
11.1
作者：
Sissler, M;Delorme, C;Francklyn, C
通讯作者：
Francklyn, C
影响因子：
14.8
作者：
Sajish, Mathew;Zhou, Quansheng;Kishi, Shuji;Valdez, Delgado M., Jr.;Kapoor, Mili;Guo, Min;Lee, Sunhee;Kim, Sunghoon;Yang, Xiang-Lei;Schimmel, Paul
通讯作者：
Schimmel, Paul
影响因子：
6.9
作者：
Moschopoulos A;Derbyshire P;Byrne ME
通讯作者：
Byrne ME