Fluoxetine treatment of children and adolescents with Tourette's and obsessive compulsive disorders: preliminary clinical experience.
Fluoxetine treatment of children and adolescents with Tourette's and obsessive compulsive disorders: preliminary clinical experience.
复制标题
氟西汀治疗儿童和青少年抽动秽语症和强迫症：初步临床经验。
DOI：
10.1097/00004583-199001000-00008
复制
发表时间：
1990
影响因子：
13.3
通讯作者：
Woolston,JL
中科院分区：
文献类型：
--
作者：
Riddle,MA;Hardin,MT;King,R;Scahill,L;Woolston,JL
盐酸氟西汀是第一个在美国上市的选择性5-羟色胺摄取抑制剂。本报告描述了氟西汀治疗10例儿童和青少年（8 - 15岁）原发性强迫症（OCD）或抽动秽语综合征（TS）+OCD的初步临床经验。一般而言，氟西汀以每天10或40 mg的剂量给药4 - 20周，耐受性良好。不良反应包括4例患者的行为激越/激活和2例患者的轻度胃肠道症状。在7名进行随访心电图的儿童中没有发现异常。10例患者中有5例（50%）被认为是应答者;在氟西汀治疗期间，他们的强迫症状显著减轻。在原发性强迫症组（四分之二，50%）和TS +强迫症组（六分之三，50%）中，应答率相似。总之，氟西汀短期给药在儿童和青少年中似乎是安全的。需要进行安慰剂对照试验以进一步评估氟西汀的疗效。
Fluoxetine hydrochloride is the first selective serotonin uptake inhibitor introduced commercially in the United States. This report describes preliminary clinical experience with fluoxetine in 10 children and adolescents, aged 8 to 15 years, with primary obsessive compulsive disorder (OCD) or Tourette's syndrome (TS) plus OCD. In general, fluoxetine, which was administered from 4 to 20 weeks at a dosage of 10 or 40 mg per day, was well tolerated. Adverse effects included behavioral agitation/activation in four patients and mild gastrointestinal symptoms in two patients. No abnormalities were noted in the seven children who had follow-up EKGs. Five of the 10 patients (50%) were considered responders; their obsessive-compulsive symptoms decreased substantially during treatment with fluoxetine. Responder rates were similar in the primary OCD (two of four, 50%) and TS + OCD (three of six, 50%) groups. In conclusion, short-term fluoxetine administration appears to be safe in children and adolescents. Placebo-controlled trials are needed to further assess the efficacy of fluoxetine.
登录
查看更多内容
影响因子：
--
作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
影响因子：
2.9
作者：
S. Turner;R. Jacob;D. Beidel;J. Himmelhoch
通讯作者：
J. Himmelhoch
DOI：
10.1097/00004583-198907000-00019
发表时间：
1989-07-01
影响因子：
13.3
作者：
RIDDLE, MA;BROWN, N;WOOLSTON, JL
通讯作者：
WOOLSTON, JL
氟西汀治疗抽动秽语综合征患者的强迫行为。
DOI：
10.1176/ajp.145.9.1173a
发表时间：
1988
期刊：
The American journal of psychiatry
影响因子：
--
作者：
M. Riddle;J. Leckman;M. Hardin;G. Anderson;D. Cohen
通讯作者：
D. Cohen
氟西汀治疗强迫症的公开试验。
DOI：
10.1176/ajp.146.7.909
发表时间：
1989
期刊：
The American journal of psychiatry
影响因子：
--
作者：
M. Jenike;L. Buttolph;L. Baer;Joseph N. Ricciardi;A. Holland
通讯作者：
A. Holland