Interleukins in Thyroid Cancer: From Basic Researches to Applications in Clinical Practice

Interleukins in Thyroid Cancer: From Basic Researches to Applications in Clinical Practice
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白细胞介素在甲状腺癌中的作用:从基础研究到临床应用

DOI:
10.3389/fimmu.2020.01124
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发表时间:
2020-06
期刊:
Front Immunol
影响因子:
--
通讯作者:
Luo QY
Luo QY
中科院分区:
其他
文献类型:
--
作者:
Xi C;Zhang GQ;Sun ZK;Song HJ;Shen CT;Chen XY;Sun JW;Qiu ZL;Luo QY

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炎症对许多癌症的肿瘤发生和进展至关重要。肿瘤微环境中的炎症分子发挥促肿瘤或抗肿瘤作用。其中,白细胞介素是一类小分子蛋白,主要由CD3+和CD4+ T淋巴细胞产生,在细胞间通讯中起重要作用。大量研究证实,白细胞介素与甲状腺癌密切相关。白细胞介素调节甲状腺癌细胞的增殖和迁移,在鉴别甲状腺良恶性疾病、预测肿瘤发生风险、评估预后和监测甲状腺癌复发等方面具有广阔的应用前景。此外,白细胞介素在甲状腺癌治疗中的有效应用已被一些细胞和动物研究所证实。本文就白细胞介素在甲状腺癌中的作用机制及其在甲状腺癌临床中的应用作一综述,以期对白细胞介素在甲状腺癌中的研究进展有所帮助。
Inflammation is crucial to tumorigenesis and progression of many cancers. Inflammatory molecules in tumor microenvironment exert pro- or anti-tumor effects. Among them, interleukin, mainly produced by CD3+ and CD4+ T lymphocytes, is a class of small molecule proteins which play an important role in intercellular communication. Numerous studies have confirmed that interleukins are closely related to thyroid cancer. Interleukins regulate the proliferation and migration of thyroid cancer cells and they have prospects in discriminating benign and malignant thyroid diseases, predicting the risk of tumorigenesis, evaluating the prognosis and monitoring the recurrence of thyroid cancer. Besides, the effective application of interleukins in treatment of thyroid cancer has been confirmed by some cell and animal researches. The present review will introduce the potential mechanisms of interleukins in thyroid cancer and focus on the applications of interleukins in clinical practice of thyroid cancer, which will help update understanding of the progress of interleukins researches in thyroid cancer.
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