Systemic inflammation moderates the association of prior concussion with hippocampal volume and episodic memory in high school and collegiate athletes.
Systemic inflammation moderates the association of prior concussion with hippocampal volume and episodic memory in high school and collegiate athletes.
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DOI：
10.1016/j.bbi.2020.07.024
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Meier TB
中科院分区：
文献类型：
--
作者：
Brett BL;Savitz J;Nitta M;España L;Teague TK;Nelson LD;McCrea MA;Meier TB
有必要确定为什么先前的脑震荡与一些退役和现役运动员的不良后果有关。我们研究了血清炎症标志物是否调节了活跃的高中和大学运动员的脑震荡与海马体积和神经行为功能的关系。运动员（N=201）完成了季前临床测试和血清采集（C-反应蛋白[CRP];白细胞介素-6 [IL]-6; IL-1受体拮抗剂[RA]）和季内神经成像。线性混合效应模型研究了先前脑震荡与炎症标志物、自我报告的症状、神经认知功能和海马体积的相关性。模型检查炎症标志物是否调节脑震荡史和海马体积和/或临床测量的关联。脑震荡病史与较高的症状严重程度显著相关，p=0.012，但与海马体积或炎症标志物无关（p>0.05）。对于海马体积，观察到先前脑震荡和CRP的显著相互作用，p=0.006。随访分析表明，在高水平的CRP，运动员有两个或两个以上的先前脑震荡有较小的海马体积相比，运动员没有先前脑震荡，p=0.008。先前脑震荡和IL-1 RA水平对记忆评分有显著的相互作用，p=0.044，即，在低水平的IL-1 RA下，有两次或两次以上脑震荡的运动员比没有脑震荡的运动员的记忆表现更差（p=0.014）。研究结果表明，某些全身性炎症标志物缓和了先前脑震荡与海马体积和情景记忆表现之间的关联。目前的研究结果突出了预测高危个体的潜在标志物，并确定了减轻累积脑震荡长期不良后果的治疗靶点。
There is a need to determine why prior concussion has been associated with adverse outcomes in some retired and active athletes. We examined whether serum inflammatory markers moderate the associations of prior concussion with hippocampal volumes and neurobehavioral functioning in active high school and collegiate athletes. Athletes (N=201) completed pre-season clinical testing and serum collection (C-reactive protein [CRP]; Interleukin-6 [IL]-6; IL-1 receptor antagonist [RA]) and in-season neuroimaging. Linear mixed-effects models examined associations of prior concussion with inflammatory markers, self-reported symptoms, neurocognitive function, and hippocampal volumes. Models examined whether inflammatory markers moderated associations of concussion history and hippocampal volume and/or clinical measures. Concussion history was significantly associated with higher symptom severity, p=0.012, but not hippocampal volume or inflammatory markers (ps>0.05). A significant interaction of prior concussion and CRP was observed for hippocampal volume, p=0.006. Follow-up analyses showed that at high levels of CRP, athletes with two or more prior concussions had smaller hippocampal volume compared to athletes without prior concussion, p=0.008. There was a significant interaction between prior concussion and levels of IL-1RA on memory scores, p=0.044, i.e., at low levels of IL-1RA, athletes with two or more concussions had worse memory performance than those without prior concussion (p=0.014). Findings suggest that certain markers of systemic inflammation moderate the association between prior concussion and hippocampal volume and episodic memory performance. Current findings highlight potential markers for predicting at-risk individuals and identify therapeutic targets for mitigating the long-term adverse consequences of cumulative concussion.
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影响因子：
11
作者：
Felger JC;Haroon E;Patel TA;Goldsmith DR;Wommack EC;Woolwine BJ;Le NA;Feinberg R;Tansey MG;Miller AH
通讯作者：
Miller AH
DOI：
10.1016/j.bbi.2016.01.017
发表时间：
2016-11
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Chesnokova V;Pechnick RN;Wawrowsky K
通讯作者：
Wawrowsky K
影响因子：
4.8
作者：
Chin, Esther Y.;Nelson, Lindsay D.;McCrea, Michael A.
通讯作者：
McCrea, Michael A.
影响因子：
2.7
作者：
Adler, Caleb M.;DelBello, Melissa P.;Divine, Jon
通讯作者：
Divine, Jon
影响因子：
6.3
作者：
Helmy, Adel;Guilfoyle, Mathew R.;Hutchinson, Peter J.
通讯作者：
Hutchinson, Peter J.