Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009-2010.

Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009-2010.
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DOI:
10.3201/eid1711.110649
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发表时间:
2011-11
影响因子:
11.8
通讯作者:
Morishima T
Morishima T
中科院分区:
医学2区
文献类型:
--
作者:
Okumura A;Nakagawa S;Kawashima H;Muguruma T;Saito O;Fujimoto J;Toida C;Kuga S;Imamura T;Shimizu T;Kondo N;Morishima T

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为了明确日本儿童与2009年H1N1流感大流行相关的死亡原因,我们回顾性研究了截至2010年3月31日死于2009年H1N1流感大流行的41例年龄<20岁的患者。通过与主治医生的访谈和图表回顾收集数据。患者中位年龄为59个月;三分之一的人有先前存在的疾病。死亡原因被分类为意外心肺骤停15例,脑病15例,呼吸衰竭6例。先前存在的呼吸或神经系统疾病在呼吸衰竭患者中更常见,而在意外心肺骤停患者中更少见。日本2009年甲型H1N1流感大流行儿童死亡的主要原因是脑病和意外的心肺骤停。与呼吸衰竭相关的死亡并不常见,主要发生在已有疾病的儿童中。疫苗使用和公众教育对于减少流感相关疾病和死亡是必要的。
To clarify the cause of deaths associated with pandemic (H1N1) 2009 among children in Japan, we retrospectively studied 41 patients <20 years of age who had died of pandemic (H1N1) 2009 through March 31, 2010. Data were collected through interviews with attending physicians and chart reviews. Median age of patients was 59 months; one third had a preexisting condition. Cause of death was categorized as unexpected cardiopulmonary arrest for 15 patients, encephalopathy for 15, and respiratory failure for 6. Preexisting respiratory or neurologic disorders were more frequent in patients with respiratory failure and less frequent in patients with unexpected cardiopulmonary arrest. The leading causes of death among children with pandemic (H1N1) 2009 in Japan were encephalopathy and unexpected cardiopulmonary arrest. Deaths associated with respiratory failure were infrequent and occurred primarily among children with preexisting conditions. Vaccine use and public education are necessary for reducing influenza-associated illness and death.
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