Correlation between the Prostaglandin D2/E2 Ratio in Nasal Polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma.
Correlation between the Prostaglandin D2/E2 Ratio in Nasal Polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma.
复制标题
鼻息肉中前列腺素 D2/E2 比率与支气管哮喘相关慢性鼻窦炎顽固性病理生理学之间的相关性。
DOI：
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发表时间：
2008
影响因子：
6.8
通讯作者：
H. Moriyama
中科院分区：
文献类型：
--
作者：
T. Yoshimura;M. Yoshikawa;N. Otori;S. Haruna;H. Moriyama
背景
传统疗法难治的慢性鼻窦炎（CRS）患者的患病率似乎正在增加。在这些情况下，CRS 往往与支气管哮喘 (BA)，尤其是阿司匹林不耐受哮喘 (AIA) 相关。另一方面，花生四烯酸代谢物在 BA 发病机制中的作用已被广泛研究。我们试图评估前列腺素 D2 (PGD2) 和前列腺素 E2 (PGE2) 在 CRS 顽固性病理生理学中的作用。
方法
样本取自我院 40 例接受内窥镜鼻窦手术 (ESS) 的患者的鼻息肉和粘膜。 CRS患者鼻息肉标本分为三组：CRS-AIA组，由CRS并发AIA患者标本组成；CRS-ATA组，由伴有阿司匹林耐受性哮喘（ATA）的CRS患者标本组成；CRS-NA组，由无BA的CRS患者标本组成。从样本中提取 PGD2 和 PGE2 并进行定量。
结果
CRS-ATA组鼻息肉中PGD2的浓度显着较高。 CRS-AIA 组鼻息肉中 PGE2 浓度最低。 CRS-AIA 组的 PGD2/PGE2 比率最高。
结论
此前有报道称，AIA并发的CRS最容易出现反复缓解和复发的情况，因而最为棘手。因此，我们可以说 PGD2/PGE2 比率反映了 CRS 的棘手性质。
BACKGROUND
The prevalence of patients with chronic rhinosinusitis (CRS) refractory to traditional therapy appears to be on the increase. In these cases, CRS tends to be associated with bronchial asthma (BA), especially, aspirin-intolerant asthma (AIA). On the other hand, arachidonic acid metabolites have been extensively investigated in the pathogenesis of BA. We sought to assess the role of prostaglandin D2 (PGD2) and prostaglandin E2 (PGE2) in the recalcitrant pathophysiology of CRS.
METHODS
Samples were prepared from the nasal polyps and mucosa of 40 patients undergoing endoscopic sinus surgery (ESS) at our hospital. The nasal polyp specimens obtained from the patients with CRS were divided into three groups, as follows: the CRS-AIA group, consisting of specimens obtained from patients with CRS complicated by AIA, the CRS-ATA group, consisting of specimens obtained from patients with CRS associated with aspirin-tolerant asthma (ATA), and the CRS-NA group, consisting of specimens obtained from CRS patients without BA. PGD2 and PGE2 were extracted from the specimens and quantified.
RESULTS
The concentrations of PGD2 were significantly higher in the nasal polyps of the CRS-ATA group. The concentrations of PGE2 were lowest in the nasal polyps of the CRS-AIA group. The PGD2/PGE2 ratio was highest in the CRS-AIA group.
CONCLUSIONS
It has previously been reported that CRS complicated by AIA is most likely to be characterized by repeated remissions and relapses, and is thus the most intractable. We may therefore say that the PGD2/PGE2 ratio reflects the intractable nature of CRS.
影响因子：
2.9
作者：
Cao, Hongmei;Xiao, Lei;van Breemen, Richard B.
通讯作者：
van Breemen, Richard B.
DOI：
10.1016/0167-5699(91)90064-z
发表时间：
1991-10-01
期刊：
IMMUNOLOGY TODAY
影响因子：
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作者：
PHIPPS, RP;STEIN, SH;ROPER, RL
通讯作者：
ROPER, RL