Increased hepatocellular carcinoma risk in chronic hepatitis B patients with persistently elevated serum total bile acid: a retrospective cohort study.
Increased hepatocellular carcinoma risk in chronic hepatitis B patients with persistently elevated serum total bile acid: a retrospective cohort study.
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血清总胆汁酸持续升高的慢性乙型肝炎患者肝细胞癌风险增加：一项回顾性队列研究
DOI：
10.1038/srep38180
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发表时间：
2016-12-01
影响因子：
4.6
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Wang H;Shang X;Wan X;Xiang X;Mao Q;Deng G;Wu Y
为了探讨慢性乙型肝炎患者血清总胆汁酸的长期变化与肝细胞癌之间的关系，我们对2262例接受常规抗病毒治疗的慢性乙型肝炎患者进行了回顾性队列研究，研究数据来自西南医院肝炎生物库项目2004年至2014年的数据。根据随访期间血清总胆汁酸持续升高的情况，将患者分为3组：血清总胆汁酸不低、中、高持续升高。使用Cox比例风险模型和Kaplan-Meier分析（包括患者人口学和临床特征信息）估计血清总胆汁酸持续升高与肝细胞癌之间的关系。在14756.5人年的回顾性随访中，有62例肝细胞癌病例。与非低持续性总胆汁酸升高患者相比，多因素校正风险比（95%可信区间）为2.37(1.16-4.84)，中、高持续性总胆汁酸升高患者的风险比为2.57（1.28-5.16）。我们的研究结果表明，血清总胆汁酸持续升高是慢性乙型肝炎患者肝细胞癌的一个独立危险因素。
To investigate the association between long-term changes of serum total bile acid and hepatocellular carcinoma in chronic hepatitis B patients, we did a retrospective cohort study of 2262 chronic hepatitis B patients with regular antiviral treatment using data from the Hepatitis Biobank at Southwest Hospital Program from 2004 to 2014. Patients in the study were classified into 3 groups according to persistence of elevated serum total bile acid during follow-up: none-low, medium, and high persistence of elevated serum total bile acid. The association between persistence of elevated serum total bile acid and hepatocellular carcinoma was estimated using Cox proportional hazard models and Kaplan-Meier analysis including information about patients’ demographic and clinical characteristics. There were 62 hepatocellular carcinoma cases during a total follow-up of 14756.5 person-years in the retrospective study. Compared to patients with none-low persistence of elevated total bile acid, the multivariate adjusted hazard ratios (95% confidence interval) were 2.37 (1.16–4.84), and 2.57 (1.28–5.16) for patients with medium, and high persistence of elevated total bile acid. Our findings identified persistence of elevated serum total bile acid as an independent risk factor of hepatocellular carcinoma in chronic hepatitis B patients.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
影响因子：
25.7
作者：
Beyoglu, Diren;Idle, Jeffrey R.
通讯作者：
Idle, Jeffrey R.
DOI：
10.1093/jnci/djn243
发表时间：
2008-08-20
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Yang HI;Yeh SH;Chen PJ;Iloeje UH;Jen CL;Su J;Wang LY;Lu SN;You SL;Chen DS;Liaw YF;Chen CJ;REVEAL-HBV Study Group
通讯作者：
REVEAL-HBV Study Group
影响因子：
13.5
作者：
Hosaka, Tetsuya;Suzuki, Fumitaka;Kumada, Hiromitsu
通讯作者：
Kumada, Hiromitsu