Genome-wide studies of the transcriptional regulation by p53.

Genome-wide studies of the transcriptional regulation by p53.
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p53 转录调控的全基因组研究。

DOI:
10.1016/j.bbagrm.2012.02.002
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发表时间:
2012
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
Huang,Jing
Huang,Jing
中科院分区:
--
文献类型:
--
作者:
Li,Mangmang;He,Yunlong;Feng,Xi;Huang,Jing

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抑癌基因p53可以说是保护基因组的最重要的转录因子。虽然很明显p53的转录活性是其肿瘤抑制功能所必需的,但其潜在的机制在很大程度上仍然未知。在过去的几年中,全基因组方法为p53的肿瘤抑制功能提供了新的见解。这篇简短的综述总结了使用全基因组方法研究这些功能的最新进展,并对这一迅速发展的领域提供了一些观点。本文是特刊的一部分,题为:时间和空间中的染色质。
The tumor suppressor p53 is arguably the most important transcription factor that safe-guards the genome. Although it is clear that the transcriptional activity of p53 is required for its tumor suppressive function, the underlying mechanisms are still largely unknown. In the past several years, genome-wide approaches have provided novel insights into the tumor suppressive functions of p53. This mini-review summarizes recent progress in studying these functions using genome-wide approaches, and offers some perspectives on this rapidly expanding field. This article is part of a Special Issue entitled: Chromatin in time and space.
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