Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex.
Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex.
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DOI：
10.1038/s41593-018-0121-5
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发表时间：
2018-05
影响因子：
25
通讯作者：
Bergles DE
中科院分区：
文献类型：
--
作者：
Hughes EG;Orthmann-Murphy JL;Langseth AJ;Bergles DE
成年中枢神经系统中少突胶质细胞的产生提供了一种使回路特性适应生活经历变化的方法。然而，少突胶质细胞的动力学和髓鞘重塑在成熟的大脑中的程度知之甚少。使用纵向在体内双光子成像的少突胶质细胞和它们的祖细胞在小鼠大脑皮层，我们表明，髓鞘形成是一个低效的和延长的过程中，有一半的最终补体少突胶质细胞产生后四个月的年龄。成功整合的少突胶质细胞在无髓鞘和稀疏髓鞘的轴突上形成新的鞘，并且非常稳定，逐渐改变髓鞘形成的模式。感觉富集强烈增加少突胶质细胞整合，但没有改变现有鞘的长度。这种成熟皮层中髓鞘形成的经验依赖性增强可能会加速这些回路中的信息传递，并通过提供额外的代谢支持来加强轴突维持活动的能力。
The generation of oligodendrocytes in the adult CNS provides a means to adapt the properties of circuits to changes in life experience. However, little is known about the dynamics of oligodendrocytes and the extent of myelin remodeling in the mature brain. Using longitudinal in vivo two photon imaging of oligodendrocytes and their progenitors in the mouse cerebral cortex, we show that myelination is an inefficient and extended process, with half of the final complement of oligodendrocytes generated after four months of age. Oligodendrocytes that successfully integrated formed novel sheaths on unmyelinated and sparsely myelinated axons, and were extremely stable, gradually changing the pattern of myelination. Sensory enrichment robustly increased oligodendrocyte integration, but did not change the length of existing sheaths. This experience-dependent enhancement of myelination in the mature cortex may accelerate information transfer in these circuits and strengthen the ability of axons to sustain activity by providing additional metabolic support.
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影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
影响因子：
25
作者：
Kang, Shin H.;Li, Ying;Fukaya, Masahiro;Lorenzini, Ileana;Cleveland, Don W.;Ostrow, Lyle W.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
影响因子：
158.5
作者：
Chang, A;Tourtellotte, WW;Trapp, BD
通讯作者：
Trapp, BD
神经元活动会影响体内髓鞘形成的轴突选择。
影响因子：
25
作者：
Hines, Jacob H.;Ravanelli, Andrew M.;Schwindt, Rani;Scott, Ethan K.;Appel, Bruce
通讯作者：
Appel, Bruce
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H