The Role of Peroxiredoxins in Cancer Development.
The Role of Peroxiredoxins in Cancer Development.
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DOI：
10.3390/biology12050666
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发表时间：
2023-04-28
期刊：
影响因子：
4.2
通讯作者：
Wei, Qiou
中科院分区：
文献类型：
--
作者：
Thapa, Pratik;Jiang, Hong;Ding, Na;Hao, Yanning;Alshahrani, Aziza;Wei, Qiou
活性氧(ROS)是氧的不稳定衍生物，是作为生物反应的产物或双产物自然产生的。ROS，如过氧化氢，可用于防御感染性病原体，并在生物系统中作为信使。然而，过量的ROS会损害DNA、脂质和蛋白质，可能会使它们的功能失活或改变。人体用来停止产生ROS、中和过量ROS或修复ROS造成的损伤的分子被称为抗氧化剂。过氧化还蛋白(Peroxiredoxins，Prxs)是一种抗氧化酶，存在于从细菌到人类的各种物种中，保护细胞免受ROS的伤害。近年来，对Prxs在正常生理和不同疾病中的作用的认识取得了很大进展。在这篇综述中，我们简要总结了关于Prxs在癌症中的最新发现。过氧化还蛋白(Peroxiredoxins，Prxs)是一种广泛存在于人体组织中的抗氧化酶。Prxs在古生物、细菌和真核生物中表达，通常以多种亚型表达。由于它们在不同的细胞器中大量表达，以及对H_2O_2的特殊敏感性，Prx是抵抗氧化应激的第一批防御系统之一。Prxs经历可逆的氧化成二硫化物，一些家族成员在进一步氧化时执行伴侣或磷脂酶功能。Prx在癌细胞中上调。研究表明，Prxs可以在各种癌症中发挥肿瘤促进剂的作用。这篇综述的主要目的是总结关于Prx在常见癌症类型中的作用的新发现。研究表明，Prxs可以影响炎症细胞和成纤维细胞的分化、细胞外基质的重塑和干细胞的调节。由于与正常细胞相比，侵袭性癌细胞具有更高的细胞内ROS水平，可用于增殖和转移，因此了解主要抗氧化剂(如Prxs)的调节和功能至关重要。这些小但强大的蛋白质可能被证明是改善癌症治疗和患者生存的关键。
Reactive oxygen species (ROS) are unstable derivatives of oxygen that are generated naturally as products or biproducts of biological reactions. ROS, such as hydrogen peroxide, can be utilized for defense against infectious agents and as messengers in the biological system. However, excess ROS can damage DNA, lipids, and proteins, possibly inactivating or altering their functions. The molecules utilized by the body to stop production of ROS, to neutralize excess ROS, or to repair damage caused by ROS are known as antioxidants. Peroxiredoxins (Prxs) are one of the antioxidant enzymes expressed in species from bacteria to humans that protect cells against ROS. In recent years, great progress has been made in understanding the role of Prxs in normal physiology and in different diseases. In this review, we have briefly summarized the recent findings regarding Prxs in cancer. Peroxiredoxins (Prxs) are antioxidant enzymes with ubiquitous expression in human tissues. Prxs are expressed in archaea, bacteria, and eukaryota, often in multiple isoforms. Because of their abundant expression in different cellular organelles and extraordinary sensitivity to H2O2, Prxs are among the first defenses against oxidative stress. Prxs undergo reversible oxidation to disulfides, and some family members perform chaperone or phospholipase functions upon further oxidation. Prxs are upregulated in cancer cells. Research has suggested that Prxs can function as tumor promoters in various cancers. The major objective of this review is to summarize novel findings regarding the roles of Prxs in common cancer types. Prxs have been shown to influence differentiation of inflammatory cells and fibroblasts, remodeling of extracellular matrix, and regulation of stemness. Since aggressive cancer cells have higher intracellular levels of ROS that they can utilize to proliferate and metastasize compared to normal cells, it is critical that we understand the regulation and functions of primary antioxidants such as Prxs. These small but mighty proteins could prove to be key for improving cancer therapeutics and patient survival.
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影响因子：
11.2
作者：
Fiskus W;Coothankandaswamy V;Chen J;Ma H;Ha K;Saenz DT;Krieger SS;Mill CP;Sun B;Huang P;Mumm JS;Melnick AM;Bhalla KN
通讯作者：
Bhalla KN
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影响因子：
4.8
作者：
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通讯作者：
Wei, Qiou
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影响因子：
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影响因子：
6.4
作者：
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影响因子：
64.8
作者：
Edgar, Rachel S.;Green, Edward W.;Zhao, Yuwei;van Ooijen, Gerben;Olmedo, Maria;Qin, Ximing;Xu, Yao;Pan, Min;Valekunja, Utham K.;Feeney, Kevin A.;Maywood, Elizabeth S.;Hastings, Michael H.;Baliga, Nitin S.;Merrow, Martha;Millar, Andrew J.;Johnson, Carl H.;Kyriacou, Charalambos P.;O'Neill, John S.;Reddy, Akhilesh B.
通讯作者：
Reddy, Akhilesh B.