Microbial production of hyaluronic acid: current state, challenges, and perspectives.
Microbial production of hyaluronic acid: current state, challenges, and perspectives.
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DOI：
10.1186/1475-2859-10-99
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发表时间：
2011-11-16
影响因子：
6.4
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Liu L;Liu Y;Li J;Du G;Chen J
透明质酸（HA）是由β-1，3-N-乙酰葡萄糖胺和β-1，4-葡萄糖醛酸的重复二糖单元组成的天然线性聚合物，分子量高达600万道尔顿。HA具有优异的粘弹性、高保湿能力和高生物相容性，在医药、化妆品和保健品中具有广泛的应用。传统的HA是从鸡冠中提取的，现在主要通过链球菌发酵生产。最近，由于避免了潜在的毒素，通过重组系统生产HA受到越来越多的关注。本文综述了HA的研究历史和目前的商业化市场，深入分析了利用动物链球菌和重组系统生产HA的现状，最后讨论了微生物生产HA所面临的挑战，并提出了应对挑战的几个研究要点。
Hyaluronic acid (HA) is a natural and linear polymer composed of repeating disaccharide units of β-1, 3-N-acetyl glucosamine and β-1, 4-glucuronic acid with a molecular weight up to 6 million Daltons. With excellent viscoelasticity, high moisture retention capacity, and high biocompatibility, HA finds a wide-range of applications in medicine, cosmetics, and nutraceuticals. Traditionally HA was extracted from rooster combs, and now it is mainly produced via streptococcal fermentation. Recently the production of HA via recombinant systems has received increasing interest due to the avoidance of potential toxins. This work summarizes the research history and current commercial market of HA, and then deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and finally discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges.
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影响因子：
4.4
作者：
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通讯作者：
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