High-resolution functional MRI identified distinct global intrinsic functional networks of nociceptive posterior insula and S2 regions in squirrel monkey brain.
High-resolution functional MRI identified distinct global intrinsic functional networks of nociceptive posterior insula and S2 regions in squirrel monkey brain.
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DOI：
10.1016/j.neuroimage.2017.04.067
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发表时间：
2017-07-15
期刊：
影响因子：
5.7
通讯作者：
Chen LM
中科院分区：
文献类型：
--
作者：
Wu R;Wang F;Yang PF;Chen LM
大量的功能成像和电生理研究表明，次级躯体感觉皮层（S2）和后躯体感觉皮层（pIns）的两个相邻区域是伤害性信息处理和疼痛感知的核心区域。在这项研究中，我们测试的假设，S2-pIns连接作为一个枢纽连接不同的感觉和情感的伤害性处理网络在松鼠猴大脑。在9.4T下，我们首先用高分辨率fMRI绘制了对伤害性热刺激做出反应的脑区，然后使用基于种子的静息态fMRI（rsfMRI）分析来描绘和细化近端S2和pIns区域的全局内在功能连接回路。在每个受试者中，在许多脑区检测到伤害性（47.5 °C）热诱发的fMRI激活，包括初级躯体感觉（S1），S2，pIns，7 b区，前扣带皮层（ACC），初级运动皮层（M1），前额叶皮层（PF），辅助运动区（SMA），丘脑和尾状核。以S2和pIns中的热诱发fMRI激活灶为种子，体素全脑静息态功能连接（rsFC）分析显示，对侧S2和pIns之间以及同侧半球相应区域之间存在强大的功能连接。空间相似性和重叠分析确定每个区域作为两个不同的内在功能网络的一部分，有7%的重叠：感觉S2-S1区7 b和情感pIns-ACC-PCC网络。此外，在伤害性S2和pIns区域的组合rsFC图与伤害性热诱发激活图之间观察到高度重叠。总之，我们的研究为S2和pIns伤害感受区域存在两个不同的内在功能网络提供了证据，并且这两个网络通过S2-pIns连接而连接。参与处理伤害性输入的大脑区域在休息时也高度互连。在麻醉状态下，S1-S2-area 7 b和pIns-ACC-PCC rsFC网络的存在强调了它们在处理伤害性信息中的基本作用。
Numerous functional imaging and electrophysiological studies in humans and animals indicate that the two contiguous areas of secondary somatosensory cortex (S2) and posterior insula (pIns) are core regions in nociceptive processing and pain perception. In this study, we tested the hypothesis that the S2-pIns connection serves as a hub for connecting distinct sensory and affective nociceptive processing networks in the squirrel monkey brain. At 9.4T, we first mapped the brain regions that respond to nociceptive heat stimuli with high-resolution fMRI, and then used seed-based resting-state fMRI (rsfMRI) analysis to delineate and refine the global intrinsic functional connectivity circuits of the proximal S2 and pIns regions. In each subject, nociceptive (47.5 °C) heat-evoked fMRI activations were detected in many brain regions, including primary somatosensory (S1), S2, pIns, area 7b, anterior cingulate cortex (ACC), primary motor cortex (M1), prefrontal cortex (PF), supplementary motor area (SMA), thalamus, and caudate. Using the heat-evoked fMRI activation foci in S2 and pIns as the seeds, voxel-wise whole-brain resting-state functional connectivity (rsFC) analysis revealed strong functional connections between contralateral S2 and pIns, as well as their corresponding regions in the ipsilateral hemisphere. Spatial similarity and overlap analysis identified each region as part of two distinct intrinsic functional networks with 7% overlap: sensory S2-S1-area 7b and affective pIns-ACC-PCC networks. Moreover, a high degree of overlap was observed between the combined rsFC maps of nociceptive S2 and pIns regions and the nociceptive heat-evoked activation map. In summary, our study provides evidence for the existence of two distinct intrinsic functional networks for S2 and pIns nociceptive regions, and these two networks are joined via the S2-pIns connection. Brain regions that are involved in processing nociceptive inputs are also highly interconnected at rest. The presence of robust and distinct S1-S2-area 7b and pIns-ACC-PCC rsFC networks under anesthesia underscores their fundamental roles in processing nociceptive information.
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
DOI：
10.1073/pnas.96.14.7668
发表时间：
1999-07-06
影响因子：
11.1
作者：
Casey, KL
通讯作者：
Casey, KL
影响因子：
2.5
作者：
Coq, JO;Qi, H;Kaas, JH
通讯作者：
Kaas, JH
DOI：
10.1073/pnas.1011949107
发表时间：
2010-12-07
影响因子：
11.1
作者：
Breshears, Jonathan D.;Roland, Jarod L.;Leuthardt, Eric C.
通讯作者：
Leuthardt, Eric C.
影响因子：
2.5
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
通讯作者：
Iadarola, MJ