Depressive symptoms in the second trimester relate to low oxytocin levels in African-American women: a pilot study.
Depressive symptoms in the second trimester relate to low oxytocin levels in African-American women: a pilot study.
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DOI：
10.1007/s00737-014-0437-4
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发表时间：
2015-02
影响因子：
4.5
通讯作者：
White-Traut, Rosemary
中科院分区：
文献类型：
--
作者：
Garfield, Lindsey;Giurgescu, Carmen;Carter, C. Sue;Holditch-Davis, Diane;McFarlin, Barbara L.;Schwertz, Dorie;Seng, Julia S.;White-Traut, Rosemary
低收入的非洲裔美国妇女报告产前抑郁症状升高的频率（42%）高于全国平均水平（20%）。2012年，在美国，16.5%的非洲裔美国妇女经历了早产（少于36个完整的孕周），而白色妇女的比例为10.3%。此外，13%的非洲裔美国妇女的婴儿出生体重不足（小于2,500 g），而白色妇女的这一比例为7%。神经肽催产素的变异与围产期抑郁症、母亲行为、应激反应的调节有关，并可能与这种健康差异有关。这项调查的目的是检查与产前抑郁症状，包括血浆催产素水平和出生体重，在城市非洲裔美国妇女的样本相关的因素。怀孕的非洲裔美国妇女（N= 57）完成了调查，并在怀孕15-22周和25-37周时抽血两次。此外，还从医疗记录中收集出生数据。大量参与者在第一个（n= 20，35%）和第二个（n= 19，33%）数据点报告产前抑郁症状升高。抑郁症状在多次妊娠妇女（t（51）=-2.374，p = 0.02）、焦虑程度较高的妇女（r（47）= 0.71，p = 0.001）、胎龄较早分娩的妇女（r（51）=-0.285，p = 0.04）和没有婴儿父亲支持的妇女（F（4，48）= 2.676，p= 0.04）。催产素水平低的女性抑郁症状也高于催产素水平高的女性（F（2，47）= 3.3，p = 0.05）。此外，催产素水平低的妇女倾向于生下出生体重较低的婴儿（F（2，47）= 2.9，p = 0.06）。产前抑郁症状和产前催产素水平均与早产无关。怀孕期间焦虑程度增加且缺乏婴儿父亲支持的怀孕多胎非裔美国妇女患产前抑郁症状的风险更高。产前抑郁症状与催产素水平低和婴儿出生体重低有关。需要进一步的研究来了解产前抑郁症状，催产素和出生体重之间的机制，以便更好地了解这种健康差异。
Low-income African-American women report elevated prenatal depressive symptoms more often (42 %) than the national average (20 %). In the USA in 2012, 16.5 % of African-American women experienced a premature birth (less than 36 completed gestational weeks) compared to 10.3 % of white women. In addition, 13 % of African-American women had a low-birth weight infant (less than 2,500 g) compared to 7 % of white women. Variation in the neuropeptide, oxytocin has been implicated in perinatal depression, maternal behavior, regulation of stress responses, and may be associated with this health disparity. The purpose of this investigation was to examine factors associated with prenatal depressive symptoms, including plasma oxytocin levels and birth weight, in a sample of urban African-American women. Pregnant African-American women (N= 57) completed surveys and had blood drawn twice during pregnancy at 15–22 weeks and 25–37 weeks. In addition, birth data were collected from medical records. A large number of participants reported elevated prenatal depressive symptoms at the first (n= 20, 35 %) and the second (n= 19, 33 %) data points. Depressive symptoms were higher in multigravidas (t(51) = −2.374,p= 0.02), women with higher anxiety (r(47) = 0.71,p= 0.001), women who delivered their infants at an earlier gestational age (r(51) = −0.285,p= 0.04), and those without the support of the infant’s father (F(4, 48) = 2.676,p= 0.04). Depressive symptoms were also higher in women with low oxytocin levels than in women with high oxytocin levels (F(2, 47) = 3.3,p= 0.05). In addition, women who had low oxytocin tended to have infants with lower birth weights (F(2, 47) = 2.9,p= 0.06). Neither prenatal depressive symptoms nor prenatal oxytocin levels were associated with premature birth. Pregnant multigravida African-American women with increased levels of anxiety and lacking the baby’s father’s support during the pregnancy are at higher risk for prenatal depressive symptoms. Prenatal depressive symptoms are associated with low oxytocin levels and lower infant birth weights. Further research is needed to understand the mechanisms between prenatal depressive symptoms, oxytocin, and birth weight in order to better understand this health disparity.
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影响因子：
1.5
作者：
Kinsella MT;Monk C
通讯作者：
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影响因子：
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