Epigenetic targets of bioactive dietary components for cancer prevention and therapy.
Epigenetic targets of bioactive dietary components for cancer prevention and therapy.
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DOI：
10.1007/s13148-010-0011-5
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发表时间：
2010-12-01
影响因子：
5.7
通讯作者：
Tollefsbol, Trygve O.
中科院分区：
文献类型：
--
作者：
Meeran, Syed M.;Ahmed, Amiya;Tollefsbol, Trygve O.
对癌症表观遗传学的新兴兴趣源于表观遗传修饰几乎涉及肿瘤发生的每一步。更有趣的是，表观遗传变化是可逆的遗传变化，不是由于DNA序列的改变，但有可能改变基因表达。膳食剂由许多生物活性成分组成，其积极调节参与肿瘤发生的各种分子靶点。我们提出的证据表明，许多生物活性的饮食成分可以干扰癌症预防和治疗中的各种表观遗传靶点。这些物质包括姜黄素（姜黄）、染料木素（大豆）、茶多酚（绿色茶）、白藜芦醇（葡萄）和萝卜硫素（十字花科蔬菜）。这些生物活性成分改变癌症预防和治疗中基因激活或沉默所需的DNA甲基化和组蛋白修饰。生物活性成分介导与肿瘤发生过程中肿瘤抑制基因（如p21 WAF 1/CIP 1）的诱导和肿瘤促进基因（如人端粒酶逆转录酶）的抑制相关的表观遗传修饰。在这里，我们提出了相当多的证据表明，生物活性成分及其表观遗传靶点与癌症预防和治疗，这应该有利于新药的发现和开发。此外，我们对基本表观遗传机制的理解取得了显着进展，并且在开发强大的新技术方面取得了快速进展，例如用于灵敏和定量检测癌症生物学中表观遗传和表观基因组变化的技术，为癌症预防和治疗的新型表观遗传方法带来了巨大希望。
The emergent interest in cancer epigenetics stems from the fact that epigenetic modifications are implicated in virtually every step of tumorigenesis. More interestingly, epigenetic changes are reversible heritable changes that are not due to the alteration in DNA sequence but have potential to alter gene expression. Dietary agents consist of many bioactive ingredients which actively regulate various molecular targets involved in tumorigenesis. We present evidence that numerous bioactive dietary components can interfere with various epigenetic targets in cancer prevention and therapy. These agents include curcumin (turmeric), genistein (soybean), tea polyphenols (green tea), resveratrol (grapes), and sulforaphane (cruciferous vegetables). These bioactive components alter the DNA methylation and histone modifications required for gene activation or silencing in cancer prevention and therapy. Bioactive components mediate epigenetic modifications associated with the induction of tumor suppressor genes such as p21WAF1/CIP1 and inhibition of tumor promoting genes such as the human telomerase reverse transcriptase during tumorigenesis processes. Here, we present considerable evidence that bioactive components and their epigenetic targets are associated with cancer prevention and therapy which should facilitate novel drug discovery and development. In addition, remarkable advances in our understanding of basic epigenetic mechanisms as well as the rapid progress that is being made in developing powerful new technologies, such as those for sensitive and quantitative detection of epigenetic and epigenomic changes in cancer biology, hold great promise for novel epigenetic approaches to cancer prevention and therapy.
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影响因子：
4.8
作者：
Balasubramanyam, K;Varier, RA;Kundu, TK
通讯作者：
Kundu, TK
影响因子：
3.8
作者：
Choudhuri, Supratim;Cui, Yue;Klaassen, Curtis D.
通讯作者：
Klaassen, Curtis D.
影响因子：
37.3
作者：
Bryant CS;Kumar S;Chamala S;Shah J;Pal J;Haider M;Seward S;Qazi AM;Morris R;Semaan A;Shammas MA;Steffes C;Potti RB;Prasad M;Weaver DW;Batchu RB
通讯作者：
Batchu RB
影响因子：
4.7
作者：
Balasubramanian, Sivaprakasam;Adhikary, Gautam;Eckert, Richard L.
通讯作者：
Eckert, Richard L.
影响因子：
4.7
作者：
Bacon, JR;Williamson, G;Bao, YP
通讯作者：
Bao, YP