Antiphospholipid antibodies, systemic lupus erythematosus, and non-traumatic metatarsal fractures
Antiphospholipid antibodies, systemic lupus erythematosus, and non-traumatic metatarsal fractures
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抗磷脂抗体、系统性红斑狼疮和非外伤性跖骨骨折
DOI：
10.1136/ard.2003.016105
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发表时间：
2004
影响因子：
27.4
通讯作者：
G. Hughes
中科院分区：
文献类型：
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作者：
S. Sangle;D. D'cruz;M. Khamashta;G. Hughes
背景：应力性骨折在新兵和运动员中很常见，被认为是应激和过度使用的继发性骨折。它们较少与代谢紊乱有关，如骨质疏松症、低磷血症和糖尿病。目的：分析19例系统性红斑狼疮和抗磷脂抗体连续表现为足部疼痛的患者。所有患者均有跖骨骨折(双侧6例)，无明显外伤史。结果：19例患者中有13例出现抗磷脂综合征。在整个组中，13人骨密度正常，1人骨量减少，其他5人骨质疏松，符合WHO标准；10人接受类固醇治疗，主要是小剂量；13人接受华法林治疗。没有证据表明代谢性骨骼异常是发病的统一因素。结论：系统性红斑狼疮患者可发生无创性跖骨应力性骨折，尤其是与抗磷脂综合征相关。这些骨折的发病机制尚不清楚，但可能的原因是跖骨中的微梗塞。
Background: Stress fractures are common in military recruits and athletes and are thought to be secondary to stress and overuse. Less often they are associated with metabolic disorders such as osteoporosis, hypophosphataemia, and diabetes mellitus. Objective: Analysis of 19 patients with systemic lupus erythematosus and antiphospholipid antibodies presenting consecutively with foot pain. All had metatarsal fractures (six bilateral) without any obvious history of trauma. Results: 13 of the 19 patients had antiphospholipid syndrome. Among the whole group, 13 had normal bone mineral density, one had osteopenia, and five others had osteoporosis as defined by WHO criteria; 10 had received steroids, mostly in low dosage; 13 were receiving warfarin. There was no evidence that a metabolic bone abnormality was a unifying factor in the pathogenesis. Conclusions: Atraumatic metatarsal stress fractures may occur in SLE, particularly in association with the antiphospholipid syndrome. The pathogenesis of these fractures remains uncertain but microinfarcts in the metatarsal bones are a possible cause.
N. Toshima：“MeV 区域质子-氢碰撞的经典轨迹蒙特卡罗计算中托马斯峰的缺失”物理评论 A. 45。（1992 年）
DOI：
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通讯作者：
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影响因子：
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作者：
Wilson, WA;Gharavi, AE;Khamashta, MA
通讯作者：
Khamashta, MA