The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications.
The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications.
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DOI:
10.3389/fcvm.2021.681948
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发表时间:
2021
影响因子:
3.6
通讯作者:
Lilly B
中科院分区:
文献类型:
--
作者:
Breikaa RM;Lilly B
COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.
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