Easy-BILAG: a new tool for simplified recording of SLE disease activity using BILAG-2004 index
Easy-BILAG: a new tool for simplified recording of SLE disease activity using BILAG-2004 index
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Easy-BILAG：使用 BILAG-2004 指数简化记录 SLE 疾病活动的新工具
DOI：
10.1101/2021.07.30.21261385
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Carter L
中科院分区：
文献类型：
--
作者：
Carter L
BILBILAG-2004指数是一个全面的疾病活动性工具，但管理负担和潜在的错误频率限制了其在常规实践中的使用。我们的目的是开发一种工具，更准确，时间效率高的评分BILAG-2004指数与现有的instrument.MethodsFrequency的BILAG-2004项目进行了整理，从一个BILAG生物制品注册表（BILAG-BR）数据集的完全保真度。Easy-BILAG原型的开发是为了解决影响速度和准确性的已知问题。经过专家验证后，根据标准格式BILAG-2004，在10个病例插图的工作簿练习中验证了最终Easy-BILAG的准确性和可用性。来自14个英国中心的33名专业人员完成了验证工作。ResultsEasy-BILAG将≥5% BILAG-BR记录中存在的所有项目，加上完整的宪法和肾脏领域纳入快速单页评估。嵌入式词汇表和颜色编码有助于领域评分。第二页在需要时捕捉更罕见的表现。在验证练习中，Easy-BILAG的评分准确率中位数（96.7%）高于标准BILAG-2004文档（87.8%，P = 0.001），评分者间一致性更好。10例病例的Easy-BILAG完成时间（59.5 min）快于标准格式（80.0 min，P= 0.04）。在综合医院的风湿病学家中观察到Easy-BILAG的准确性优势（91.3vs75.0，P = 0.02），导致与三级中心的风湿病学家相同的准确性。临床医生评价Easy-BILAG为直观，方便，以及适应常规practice.ConclusionEasy-BILAG有利于更快速，准确的评分BILAG-2004在所有的临床设置，这可以改善病人的护理和生物制剂处方。凡是需要BILAG-2004评估的地方都应采用Easy-BILAG。
ObjectiveBILAG-2004 index is a comprehensive disease activity instrument for SLE but administrative burden and potential frequency of errors limits its use in routine practice. We aimed to develop a tool for more accurate, time-efficient scoring of BILAG-2004 index with full fidelity to the existing instrument.MethodsFrequency of BILAG-2004 items was collated from a BILAG-biologics registry (BILAG-BR) dataset. Easy-BILAG prototypes were developed to address known issues affecting speed and accuracy. After expert verification, accuracy and usability of the finalized Easy-BILAG was validated against standard format BILAG-2004 in a workbook exercise of 10 case vignettes. Thirty-three professionals ranging in expertise from 14 UK centres completed the validation exercise.ResultsEasy-BILAG incorporates all items present in ≥5% BILAG-BR records, plus full constitutional and renal domains into a rapid single page assessment. An embedded glossary and colour-coding assists domain scoring. A second page captures rarer manifestations when needed. In the validation exercise, Easy-BILAG yielded higher median scoring accuracy (96.7%) than standard BILAG-2004 documentation (87.8%,P= 0.001), with better inter-rater agreement. Easy-BILAG was completed faster (59.5 min) than the standard format (80.0 min,P= 0.04) for 10 cases. An advantage in accuracy was observed with Easy-BILAG use among general hospital rheumatologists (91.3vs75.0,P= 0.02), leading to equivalent accuracy as tertiary centre rheumatologists. Clinicians rated Easy-BILAG as intuitive, convenient, and well adapted for routine practice.ConclusionEasy-BILAG facilitates more rapid and accurate scoring of BILAG-2004 across all clinical settings, which could improve patient care and biologics prescribing. Easy-BILAG should be adopted wherever BILAG-2004 assessment is required.
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影响因子：
5.5
作者：
Pearce, Fiona A.;Rutter, Megan;Lanyon, Peter C.
通讯作者：
Lanyon, Peter C.
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发表时间：
2000
期刊：
The Journal of rheumatology.
影响因子：
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作者：
Ward,MM;Marx,AS;Barry,NN
通讯作者：
Barry,NN
DOI：
10.1093/rheumatology/keq026
发表时间：
2010-09
期刊：
Rheumatology (Oxford, England)
影响因子：
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作者：
Yee CS;Cresswell L;Farewell V;Rahman A;Teh LS;Griffiths B;Bruce IN;Ahmad Y;Prabu A;Akil M;McHugh N;D'Cruz D;Khamashta MA;Isenberg DA;Gordon C
通讯作者：
Gordon C
DOI：
10.1093/rheumatology/kex395
发表时间：
2018-03-01
期刊：
Rheumatology (Oxford, England)
影响因子：
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作者：
McCarthy EM;Sutton E;Nesbit S;White J;Parker B;Jayne D;Griffiths B;Isenberg DA;Rahman A;Gordon C;D'Cruz DP;Rhodes B;Lanyon P;Vital EM;Yee CS;Edwards CJ;Teh LS;Akil M;McHugh NJ;Zoma A;Bruce IN;British Isles Lupus Assessment Group Biologics Register
通讯作者：
British Isles Lupus Assessment Group Biologics Register