Epigenetic Regulations of Microglia/Macrophage Polarization in Ischemic Stroke.
Epigenetic Regulations of Microglia/Macrophage Polarization in Ischemic Stroke.
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缺血性中风中小胶质细胞/巨噬细胞极化的表观遗传调控。
DOI：
10.3389/fnmol.2021.697416
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zhan L
中科院分区：
文献类型：
--
作者：
Qiu M;Xu E;Zhan L
缺血性中风是世界范围内死亡和残疾的主要原因之一。小胶质细胞/巨噬细胞（Microglia/macrophages，microglia/macrophages）介导的神经炎症反应在缺血性脑损伤的病理过程中起重要作用。小胶质细胞作为中枢神经系统内的固有免疫细胞，在脑缺血后的微环境变化中表现出促炎或抗炎的表型。新出现的证据表明，表观遗传学修饰，不改变DNA序列的表型的可逆修饰，可能在MM极化的调节中发挥关键作用。然而，脑缺血后MM极化的表观遗传调节机制的知识仍然有限。本文就MM极化的表观遗传学调控机制，包括组蛋白修饰、非编码RNA和DNA甲基化等方面的研究进展作一综述。此外，我们还讨论了表观遗传介导的MM极化作为缺血性卒中诊断和治疗靶点的潜力。明确表观遗传学和MM极化之间的潜在机制，可能为脑缺血后神经元损伤提供有希望的治疗策略。
Ischemic stroke is one of the leading causes of death and disability worldwide. Microglia/macrophages (MMs)-mediated neuroinflammation contributes significantly to the pathological process of ischemic brain injury. Microglia, serving as resident innate immune cells in the central nervous system, undergo pro-inflammatory phenotype or anti-inflammatory phenotype in response to the microenvironmental changes after cerebral ischemia. Emerging evidence suggests that epigenetics modifications, reversible modifications of the phenotype without changing the DNA sequence, could play a pivotal role in regulation of MM polarization. However, the knowledge of the mechanism of epigenetic regulations of MM polarization after cerebral ischemia is still limited. In this review, we present the recent advances in the mechanisms of epigenetics involved in regulating MM polarization, including histone modification, non-coding RNA, and DNA methylation. In addition, we discuss the potential of epigenetic-mediated MM polarization as diagnostic and therapeutic targets for ischemic stroke. It is valuable to identify the underlying mechanisms between epigenetics and MM polarization, which may provide a promising treatment strategy for neuronal damage after cerebral ischemia.
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