Cardiovascular disease and rheumatoid arthritis: an update.

Cardiovascular disease and rheumatoid arthritis: an update.
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DOI:
10.1007/s11926-012-0271-5
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发表时间:
2012-10
影响因子:
5
通讯作者:
Charles-Schoeman, Christina
Charles-Schoeman, Christina
中科院分区:
医学2区
文献类型:
--
作者:
Charles-Schoeman, Christina

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与普通人群相比,类风湿性关节炎(RA)患者的心血管(CV)发病率和死亡率显著增加。传统的心血管风险因素和高水平的全身性炎症都与RA患者心血管风险的增加有关,但这些因素导致心血管疾病的机制仍存在重大不确定性。此外,关于如何最好地识别患有心血管疾病的高危RA患者,以及哪些一级和二级预防策略在影响心血管疾病预后方面有效,仍存在一些持续的问题。本文综述了这一领域的最新研究进展。
Patients with rheumatoid arthritis (RA) suffer significantly increased cardiovascular (CV) morbidity and mortality when compared to the general population. Both traditional CV risk factors and high levels of systemic inflammation have been linked to the increased CV risk in RA patients, but significant uncertainty remains regarding the mechanisms through which these factors contribute to CVD. In addition, ongoing questions remain regarding how best to identify RA patients at high risk for CVD, and what primary and secondary prevention strategies are effective at influencing CV outcome. The current review summarizes recent research in this field.
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