Influence of vestibular activation on respiration in humans.
Influence of vestibular activation on respiration in humans.
复制标题
前庭激活对人类呼吸的影响。
DOI：
10.1152/ajpregu.00568.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Ray,ChesterA
中科院分区：
文献类型：
--
作者：
Monahan,KevinD;Sharpe,MelissaK;Drury,Daniel;Ertl,AndrewC;Ray,ChesterA
The purpose of this study was to determine the effects of the semicircular canals and otolith organs on respiration in humans. On the basis of animal studies, we hypothesized that vestibular activation would elicit a vestibulorespiratory reflex. To test this hypothesis, respiratory measures, arterial blood pressure, and heart rate were measured during engagement of semicircular canals and/or otolith organs. Dynamic upright pitch and roll (15 cycles/min), which activate the otolith organs and semicircular canals, increased respiratory rate (Δ2 ± 1 and Δ3 ± 1 breaths/min, respectively;P< 0.05). Dynamic yaw and lateral pitch (15 cycles/min), which activate the semicircular canals, increased respiration similarly (Δ3 ± 1 and Δ2 ± 1, respectively;P< 0.05). Dynamic chair rotation (15 cycles/min), which mimics dynamic yaw but eliminates neck muscle afferent, increased respiration (Δ3 ± 1;P< 0.05) comparable to dynamic yaw (15 cycles/min). Increases in respiratory rate were graded as greater responses occurred during upright (Δ5 ± 2 breaths/min) and lateral pitch (Δ4 ± 1) and roll (Δ5 ± 1) performed at 30 cycles/min. Increases in breathing frequency resulted in increases in minute ventilation during most interventions. Static head-down rotation, which activates otolith organs, did not alter respiratory rate (Δ1 ± 1 breaths/min). Collectively, these data indicate that semicircular canals, but not otolith organs or neck muscle afferents, mediate increased ventilation in humans and support the concept that vestibular activation alters respiration in humans.
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