What are melanocytes really doing all day long...?
What are melanocytes really doing all day long...?
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DOI：
10.1111/j.1600-0625.2009.00912.x
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发表时间：
2009-09
影响因子：
3.6
通讯作者：
Schallreuter KU
中科院分区：
文献类型：
--
作者：
Plonka PM;Passeron T;Brenner M;Tobin DJ;Shibahara S;Thomas A;Slominski A;Kadekaro AL;Hershkovitz D;Peters E;Nordlund JJ;Abdel-Malek Z;Takeda K;Paus R;Ortonne JP;Hearing VJ;Schallreuter KU
翻译后摘要：每个人都知道，似乎同意，黑色素细胞在那里产生黑色素-一个有趣的，但被低估的多用途分子，能够做的远远超过提供色素和紫外线保护皮肤（1）。那么，产生黑色素的细胞呢？当没有人关注我们皮肤及其附属物的色素沉着，并且基本上没有紫外线照射时，这种树突状神经嵴衍生细胞是否仍然发挥有用（甚至重要）的功能？换句话说，表皮和毛囊黑素细胞在空闲时间--晚上，在你的床罩下--做什么呢？哺乳动物皮肤中的黑素细胞生理功能的完整组合有多少已经被真正阐明？黑素细胞的存在与否对正常表皮和/或毛囊功能（除了色素沉着和紫外线防护）以及皮肤免疫反应是否重要？黑色素细胞在紫外线防护方面是否真的像传统观点所认为的那样值得信赖？这些混杂的细胞与它们的直接上皮环境进行哪些相互作用，谁在控制谁？在试图揭示黑素细胞的“秘密身份”的过程中，从低等脊椎动物的黑素细胞和皮外黑素细胞中可以得到什么教训？当前的争议专题探讨了这些不常提出的生物学和临床上重要的问题。作为对恶性黑素细胞（2）的同伴观点文章的补充，这篇对黑素细胞生物学的批判性重新审视提供了一个关于生理黑素细胞功能缓慢出现的复杂性的古老但未被充分认识的概念和新想法的聚宝盆，并描绘了重要的，发人深省的问题，这些问题仍有待于未来的研究明确回答。
Abstract:Everyone knows and seems to agree that melanocytes are there to generate melanin – an intriguing, but underestimated multipurpose molecule that is capable of doing far more than providing pigment and UV protection to skin (1). What about the cell that generates melanin, then? Is this dendritic, neural crest‐derived cell still serving useful (or even important) functions when no‐one looks at the pigmentation of our skin and its appendages and when there is essentially no UV exposure? In other words, what do epidermal and hair follicle melanocytes do in their spare time – at night, under your bedcover? How much of the full portfolio of physiological melanocyte functions in mammalian skin has really been elucidated already? Does the presence or absence of melanoctyes matter for normal epidermal and/or hair follicle functions (beyond pigmentation and UV protection), and for skin immune responses? Do melanocytes even deserve as much credit for UV protection as conventional wisdom attributes to them? In which interactions do these promiscuous cells engage with their immediate epithelial environment and who is controlling whom? What lessons might be distilled from looking at lower vertebrate melanophores and at extracutaneous melanocytes in the endeavour to reveal the ‘secret identity’ of melanocytes? The currentControversiesfeature explores these far too infrequently posed, biologically and clinically important questions. Complementing a companion viewpoint essay on malignant melanocytes (2), this critical re‐examination of melanocyte biology provides a cornucopia of old, but under‐appreciated concepts and novel ideas on the slowly emerging complexity of physiological melanocyte functions, and delineates important, thought‐provoking questions that remain to be definitively answered by future research.
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DOI：
10.1111/j.1600-0749.1994.tb00070.x
发表时间：
1994-12-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
BOWERS, RR;LUJAN, J;VARKEY, C
通讯作者：
VARKEY, C
DOI：
10.3109/01050399009070759
发表时间：
1990-01-01
期刊：
SCANDINAVIAN AUDIOLOGY
影响因子：
--
作者：
BARRENAS, ML;LINDGREN, F
通讯作者：
LINDGREN, F
影响因子：
1.6
作者：
Calude, CS;Paun, G
通讯作者：
Paun, G
影响因子：
10.3
作者：
BUFFEY, JA;MESSENGER, AG;MACNEIL, S
通讯作者：
MACNEIL, S
影响因子：
2.9
作者：
Beuckmann, CT;Aoyagi, M;Urade, Y
通讯作者：
Urade, Y