A novel escapable social interaction test reveals that social behavior and mPFC activation during an escapable social encounter are altered by post-weaning social isolation and are dependent on the aggressiveness of the stimulus rat.
A novel escapable social interaction test reveals that social behavior and mPFC activation during an escapable social encounter are altered by post-weaning social isolation and are dependent on the aggressiveness of the stimulus rat.
复制标题
一项新颖的逃避社会互动测试表明，在逃避的社会遭遇期间的社会行为和MPFC激活会因断奶后的社会隔离而改变，并且取决于刺激大鼠的侵略性。
DOI：
10.1016/j.bbr.2016.09.025
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发表时间：
2017-01-15
影响因子：
2.7
通讯作者：
Bland, Sondra T.
中科院分区：
文献类型：
--
作者：
Goodell, Dayton J.;Ahern, Megan A.;Baynard, Jessica;Wall, Vanessa L.;Bland, Sondra T.
断奶后的社会隔离(PSI)已被证明增加攻击行为，并改变内侧前额叶皮质(MPFC)的功能，如大鼠。在这里，我们开发了一种新的逃避社交互动测试(ESIT)，除了对攻击性或非攻击性刺激大鼠的mPFC激活做出反应外，还允许量化逃避和社交行为。雄性大鼠暴露于3周的PSI(ISO)或组(GRP)住房中，并接受3次试验，包括无试验、所有试验或仅有刺激大鼠的最后一次试验。社会行为分析表明，与GRP大鼠相比，ISO大鼠在逃生室中花费的时间更少，而参与社交、攻击性梳妆和拳击的时间更多。有趣的是，在第三次试验中，所有大鼠都参与了更多量化的社会行为，并且对攻击性而不是非攻击性刺激大鼠做出反应时，逃离的时间更少。在第三次实验中，暴露于非攻击性刺激大鼠的大鼠在mPFC中的c-fos和ARC免疫反应比暴露于攻击性刺激大鼠的大鼠更强。相反，社交接触在mPFC中产生了大的PSD-95点，独立于试验次数，但仅在暴露于攻击性刺激大鼠的ISO大鼠中。研究结果表明，在可逃避的社会交往中，PSI增加了相互作用的时间和攻击性行为，并且在社交接触中刺激大鼠的攻击性是隔离和集体饲养的大鼠行为和神经结果的重要组成部分。
Post-weaning social isolation (PSI) has been shown to increase aggressive behavior and alter medial prefrontal cortex (mPFC) function in social species such as rats. Here we developed a novel escapable social interaction test (ESIT) allowing for the quantification of escape and social behaviors in addition to mPFC activation in response to an aggressive or nonaggressive stimulus rat. Male rats were exposed to 3 weeks of PSI (ISO) or group (GRP) housing, and exposed to 3 trials, with either no trial, all trials, or the last trial only with a stimulus rat. Analysis of social behaviors indicated that ISO rats spent less time in the escape chamber and more time engaged in social interaction, aggressive grooming, and boxing than did GRP rats. Interestingly, during the third trial all rats engaged in more of the quantified social behaviors and spent less time escaping in response to aggressive but not nonaggressive stimulus rats. Rats exposed to nonaggressive stimulus rats on the third trial had greater c-fos and ARC immunoreactivity in the mPFC than those exposed to an aggressive stimulus rat. Conversely, a social encounter produced an increase in large PSD-95 punctae in the mPFC independently of trial number, but only in ISO rats exposed to an aggressive stimulus rat. The results presented here demonstrate that PSI increases interaction time and aggressive behaviors during escapable social interaction, and that the aggressiveness of the stimulus rat in a social encounter is an important component of behavioral and neural outcomes for both isolation and group-reared rats.
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影响因子：
64.8
作者：
Golden SA;Heshmati M;Flanigan M;Christoffel DJ;Guise K;Pfau ML;Aleyasin H;Menard C;Zhang H;Hodes GE;Bregman D;Khibnik L;Tai J;Rebusi N;Krawitz B;Chaudhury D;Walsh JJ;Han MH;Shapiro ML;Russo SJ
通讯作者：
Russo SJ
DOI：
10.1037/h0077177
发表时间：
1975-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BLANCHARD, RJ;FUKUNAGA, K;KELLEY, MJ
通讯作者：
KELLEY, MJ
影响因子：
2.2
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
通讯作者：
Spear, LP
影响因子：
3.3
作者：
Felix-Ortiz AC;Burgos-Robles A;Bhagat ND;Leppla CA;Tye KM
通讯作者：
Tye KM
影响因子：
3.3
作者：
Gruene T;Flick K;Rendall S;Cho JH;Gray J;Shansky R
通讯作者：
Shansky R