An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation.
An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation.
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对高频振荡通气和常规机械通气期间发生的应变幅度的炎症反应的体外研究。
DOI：
10.1016/j.jbiomech.2019.03.024
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发表时间：
2019
影响因子：
2.4
通讯作者：
Harris C
中科院分区：
文献类型：
--
作者：
Harris C
在英国振荡研究 (UKOS) 中，在新生儿期随机接受高频振荡通气 (HFOV) 或传统机械通气 (CMV) 的儿童在 11 至 14 岁时肺功能良好。在 HFOV 期间，潮气量要小得多，但会产生较高的平均气道膨胀压，因此，对长期肺功能的容量依赖性影响的可能解释可能是响应于较高潮气量和应变而导致的炎症增加。我们通过评估 A549 肺泡类似细胞中白细胞介素 6 (IL-6) 和 -8 (IL-8) 的释放来测试这一假设，该试验以 0.5Hz 施加双轴机械应变，发生在模拟 CMV 期间应变的条件（5-20% 应变）和模拟 HFOV 期间应变的条件（17.5%±2.5% 应变）长达 4 小时。 CMV 期间发生的 5-20% 循环应变，与未应变对照相比，IL-6 和 IL-8 水平增加，而 HFOV 期间发生的 17.5%±2.5% 应变与 IL-6（46.31±2.66 与 56.79±3.73pg/mL）和 IL-8（1340.2±74.9 与 与 CMV 期间四小时内发生的情况相比，分泌量为 2522±248pg/mL)。这些结果可能为在新生儿期接受 HFOV 支持的 11-14 岁儿童的优越肺功能提供了可能的解释。
Children randomised in the neonatal period to high frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in the United Kingdom Oscillation study (UKOS) had superior lung function at 11 to 14 years of age. During HFOV, much smaller tidal volumes, but a higher mean airway distending pressure is delivered, hence, a possible explanation for a volume dependent effect on long term lung function could be an increase in inflammation in response to higher tidal volumes and strains. We tested that hypothesis by assessing interleukin-6 (IL-6) and -8 (IL-8) release from A549 alveolar analogue cells following biaxial mechanical strain applied at 0.5 Hz occurring during conditions mimicking strain during CMV (5–20% strain) and conditions mimicking strain during HFOV (17.5% ± 2.5% strain) for up to 4 h. Cyclic strain of 5–20%, occurring during CMV, increased levels of both IL-6 and IL-8 compared to unstrained controls, while 17.5% ± 2.5% strain, occurring during HFOV, was associated with significantly lower levels of IL-6 (46.31 ± 2.66 versus 56.79 ± 3.73 pg/mL) and IL-8 (1340.2 ± 74.9 versus 2522 ± 248 pg/mL) secretion compared to conditions occurring during CMV at four hours. These results may provide a possible explanation for the superior lung function in 11–14-year-old children who had been supported in the neonatal period by HFOV.
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DOI：
10.1097/01.aoa.0000460415.48906.43
发表时间：
2014
期刊：
Obstetric Anesthesia Digest
影响因子：
--
作者：
S. Zivanovic;J. Peacock;Mireia Alcazar;J. Lo;A. Lunt;N. Marlow;S. Calvert;A. Greenough
通讯作者：
A. Greenough
DOI：
10.1111/1440-1681.12068
发表时间：
2013-11-01
影响因子：
2.9
作者：
O'Reilly, Megan;Sozo, Foula;Harding, Richard
通讯作者：
Harding, Richard
影响因子：
3.8
作者：
G. Dimitriou;Paul Cheeseman;A. Greenough
通讯作者：
A. Greenough
影响因子：
3.3
作者：
Tschumperlin, DJ;Margulies, SS
通讯作者：
Margulies, SS
DOI：
10.1152/ajplung.1998.275.6.l1173
发表时间：
1998-12-01
影响因子：
4.9
作者：
Tschumperlin, DJ;Margulies, SS
通讯作者：
Margulies, SS