Antiviral Activities of Human Host Defense Peptides.
Antiviral Activities of Human Host Defense Peptides.
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DOI：
10.2174/0929867326666190805151654
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发表时间：
2020
影响因子：
4.1
通讯作者：
Diamond, Gill
中科院分区：
文献类型：
--
作者：
Brice, David C.;Diamond, Gill
具有广谱抗菌活性的多肽在自然界中广泛存在。由于它们参与哺乳动物天然免疫的许多不同方面，它们被称为宿主防御肽(HDPs)。由于它们的共同结构特征，包括两亲性结构和阳离子电荷，它们被广泛地显示出与微生物膜相互作用并破坏微生物膜。因此，人的高密度脂蛋白对包膜病毒以及细菌和真菌具有活性也就不足为奇了。然而，这些多肽也表现出对广泛的非包膜病毒的活性，在病毒感染的几个不同步骤中发挥作用。本文综述了人类宿主防御素的活性，包括α-防御素和β-防御素，以及唯一的人防御素LL-37对包膜和非包膜病毒的抗病毒活性。这些多肽在体外和体内具有广泛的抗病毒活性，表明它们在对抗病毒感染的先天抗病毒防御中发挥着重要作用。此外，文献表明，它们可能会被开发成抗病毒治疗药物。
Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs). Due to their common structural features, including an amphipathic structure and cationic charge, they have been widely shown to interact with and disrupt microbial membranes. Thus, it is not surprising that human HDPs have activity against enveloped viruses as well as bacteria and fungi. However, these peptides also exhibit activity against a wide range of non-enveloped viruses as well, acting at a number of different steps in viral infection. This review focuses on the activity of human host defense peptides, including alpha- and beta-defensins and the sole human cathelicidin, LL-37, against both enveloped and non-enveloped viruses. The broad spectrum of antiviral activity of these peptides, both in vitro and in vivo suggest that they play an important role in the innate antiviral defense against viral infections. Furthermore, the literature suggests that they may be developed into antiviral therapeutic agents.
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