Exposure to polycyclic aromatic hydrocarbons during pregnancy and breast tissue composition in adolescent daughters and their mothers: a prospective cohort study.
Exposure to polycyclic aromatic hydrocarbons during pregnancy and breast tissue composition in adolescent daughters and their mothers: a prospective cohort study.
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怀孕期间暴露于多环芳烃和青春期女儿及其母亲的乳腺组织成分：一项前瞻性队列研究。
DOI：
10.1186/s13058-022-01546-8
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发表时间：
2022-07-11
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影响因子：
--
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空气污染中发现的多环芳烃（PAH）具有致癌和内分泌干扰特性，可能会增加乳腺癌的风险。怀孕期间接触PAH可能特别有害，因为这是母亲和女儿的乳房组织正在经历结构和功能变化的时候。在这项研究中，我们测试了这一假设，即怀孕期间的环境PAH暴露与乳腺组织组成，测量一至二十年后，在青春期的女儿和他们的母亲。我们使用来自纽约市队列的非西班牙裔黑人和西班牙裔母女二人组（1998-2006年招募）的数据进行了前瞻性分析。在怀孕的第三个三个月，妇女穿着装有连续运行的空气采样泵的背包，连续两天测量环境暴露于8种致癌的高分子量非挥发性PAH化合物（PAH）和芘。当女儿（n = 186）和母亲（n = 175）分别达到11-20岁和29-55岁时，使用光学光谱（OS）来评估乳腺组织成分（BTC）的测量值，这些测量值与乳房X线摄影乳腺密度（公认的乳腺癌风险因素）呈正相关（水含量，胶原含量，光学指数）和负相关（脂质含量）。多变量线性回归用于评估环境PAH暴露与BTC之间的关联，总体上和怀孕期间暴露于家庭烟草烟雾（是/否）。模型根据种族/民族、年龄和OS时的体脂百分比进行了调整。环境PAH暴露（108 PAH或芘）与BTC之间没有发现总体相关性，但在女儿和母亲的含水量和光学指数方面，108 PAH与家庭烟草烟雾暴露之间存在统计学显著的相加作用（相互作用p值< 0.05）。2008年PAH暴露与较高的含水量相关（β女儿= 0.42，95% CI = 0.15-0.68; β母亲= 0.32，95% CI = 0.05-0.61）和较高的光学指数（β女儿= 0.38，95%CI = 0.12-0.64; β母亲= 0.38，95%CI = 0.12-0.65）;在非吸烟家庭中未发现相关性（交互作用p值< 0.05）。在怀孕期间暴露于环境中的108 PAH和烟草烟雾可能会协同作用，影响母亲和女儿的BTC。如果在其他队列中复制，这些发现可能对跨代乳腺癌风险具有重要意义。在线版本包含补充材料，可通过10.1186/s13058-022-01546-8获得。
Polycyclic aromatic hydrocarbons (PAH), which are found in air pollution, have carcinogenic and endocrine disrupting properties that might increase breast cancer risk. PAH exposure might be particularly detrimental during pregnancy, as this is a time when the breast tissue of both the mother and daughter is undergoing structural and functional changes. In this study, we tested the hypothesis that ambient PAH exposure during pregnancy is associated with breast tissue composition, measured one to two decades later, in adolescent daughters and their mothers. We conducted a prospective analysis using data from a New York City cohort of non-Hispanic Black and Hispanic mother–daughter dyads (recruited 1998–2006). During the third trimester of pregnancy, women wore backpacks containing a continuously operating air sampling pump for two consecutive days that measured ambient exposure to eight carcinogenic higher molecular weight nonvolatile PAH compounds (Σ8 PAH) and pyrene. When daughters (n = 186) and mothers (n = 175) reached ages 11–20 and 29–55 years, respectively, optical spectroscopy (OS) was used to evaluate measures of breast tissue composition (BTC) that positively (water content, collagen content, optical index) and negatively (lipid content) correlate with mammographic breast density, a recognized risk factor for breast cancer. Multivariable linear regression was used to evaluate associations between ambient PAH exposure and BTC, overall and by exposure to household tobacco smoke during pregnancy (yes/no). Models were adjusted for race/ethnicity, age, and percent body fat at OS. No overall associations were found between ambient PAH exposure (Σ8 PAH or pyrene) and BTC, but statistically significant additive interactions between Σ8 PAH and household tobacco smoke exposure were identified for water content and optical index in both daughters and mothers (interaction p values < 0.05). Σ8 PAH exposure was associated with higher water content (βdaughters = 0.42, 95% CI = 0.15–0.68; βmothers = 0.32, 95% CI = 0.05–0.61) and higher optical index (βdaughters = 0.38, 95% CI = 0.12–0.64; βmothers = 0.38, 95% CI = 0.12–0.65) in those exposed to household tobacco smoke during pregnancy; no associations were found in non-smoking households (interaction p values < 0.05). Exposure to ambient Σ8 PAH and tobacco smoke during pregnancy might interact synergistically to impact BTC in mothers and daughters. If replicated in other cohorts, these findings might have important implications for breast cancer risk across generations. The online version contains supplementary material available at 10.1186/s13058-022-01546-8.
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影响因子：
3.8
作者：
Blackmore, Kristina M.;Knight, Julia A.;Lilge, Lothar
通讯作者：
Lilge, Lothar
影响因子：
5.6
作者：
Jiang, Luohua;Chang, Jenny;Anton-Culver, Hoda
通讯作者：
Anton-Culver, Hoda
DOI：
10.11124/jbisrir-2017-003558
发表时间：
2018-08-01
期刊：
JBI database of systematic reviews and implementation reports
影响因子：
--
作者：
Qureshi, Rubab;Jadotte, Yuri;Watkins, Elizabeth Ann
通讯作者：
Watkins, Elizabeth Ann
DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ