Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS.
Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS.
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DOI：
10.1136/jnnp-2018-318830
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Leigh PN
中科院分区：
文献类型：
--
作者：
Broad RJ;Gabel MC;Dowell NG;Schwartzman DJ;Seth AK;Zhang H;Alexander DC;Cercignani M;Leigh PN
皮质脊髓束（CST）变性和皮质萎缩是肌萎缩性侧索硬化症（ALS）的一致特征。我们假设神经突定向弥散和密度成像（NODDI），一种多室弥散MRI模型，将揭示CST和中央前回（PCG）体内与ALS相关的微结构变化。23名散发性ALS患者和23名健康对照者接受了弥散性MRI检查。得到了神经突密度指数（NDI）、取向弥散指数（ODI）和自由水分数(各向同性隔室（ISO）。进行全脑体素分析以评估组间差异。计算标准扩散张量成像（DTI）参数进行比较。亚组分析探讨与球受累相关的NODDI参数差异。探讨NODDI参数与临床变量的相关性。在聚类水平上进行家庭误差校正后，p<0.05的结果被认为是显著的，聚类形成的p<0.001。在ALS组，NDI在CST、胼胝体和右侧PCG的广泛区域减少。右侧前内囊和右侧PCG的ODI减少。根据有无受累球而分层的亚组之间检测到NDI的显著差异。ODI和ISO与病程相关。NODDI显示CST内轴突丢失是ALS变性的核心特征。这是导致使用DTI检测到的扩散系数曲线改变的主要因素。NODDI还发现了PCG内的树突改变，表明皮层的微结构树突改变与CST轴突损伤同时发生。
Corticospinal tract (CST) degeneration and cortical atrophy are consistent features of amyotrophic lateral sclerosis (ALS). We hypothesised that neurite orientation dispersion and density imaging (NODDI), a multicompartment model of diffusion MRI, would reveal microstructural changes associated with ALS within the CST and precentral gyrus (PCG) ‘in vivo’. 23 participants with sporadic ALS and 23 healthy controls underwent diffusion MRI. Neurite density index (NDI), orientation dispersion index (ODI) and free water fraction (isotropic compartment (ISO)) were derived. Whole brain voxel-wise analysis was performed to assess for group differences. Standard diffusion tensor imaging (DTI) parameters were computed for comparison. Subgroup analysis was performed to investigate for NODDI parameter differences relating to bulbar involvement. Correlation of NODDI parameters with clinical variables were also explored. The results were accepted as significant where p<0.05 after family-wise error correction at the cluster level, clusters formed with p<0.001. In the ALS group NDI was reduced in the extensive regions of the CST, the corpus callosum and the right PCG. ODI was reduced in the right anterior internal capsule and the right PCG. Significant differences in NDI were detected between subgroups stratified according to the presence or absence of bulbar involvement. ODI and ISO correlated with disease duration. NODDI demonstrates that axonal loss within the CST is a core feature of degeneration in ALS. This is the main factor contributing to the altered diffusivity profile detected using DTI. NODDI also identified dendritic alterations within the PCG, suggesting microstructural cortical dendritic changes occur together with CST axonal damage.
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