Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability.
Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability.
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DOI：
10.1001/archgenpsychiatry.2009.24
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发表时间：
2009-05
影响因子：
--
通讯作者：
Meyer-Lindenberg, Andreas
中科院分区：
文献类型：
--
作者：
Goldman, Aaron L.;Pezawas, Lukas;Doz, Priv;Mattay, Venkata S.;Fischl, Bruce;Verchinski, Beth A.;Chen, Qiang;Weinberger, Daniel R.;Meyer-Lindenberg, Andreas
精神分裂症是一种具有主要遗传风险因素的脑部疾病，先前的研究已经确定了局部脑体积的遗传性皮质和皮质下减少。据我们所知，皮质厚度，精神分裂症的一个特别感兴趣的措施，以前没有被评估的遗传性与精神分裂症的风险。定量分析精神分裂症患者皮质厚度改变的分布和遗传度。我们使用基于表面的方法分析了正常对照、受影响患者和未受影响的兄弟姐妹的大样本。皮质厚度的诊断组之间进行了比较，在表面广泛的节点的基础上。通过计算Risch λ，在来自自动皮质包裹算法的区域中评估与疾病风险相关的遗传性。研究医院196名正常对照，115名精神分裂症患者和192名未受影响的兄弟姐妹。局部皮质厚度。逐节点映射统计显示，患者组广泛的厚度减少，最明显的是在额叶和颞叶皮层。未受影响的兄弟姐妹没有显着差异，从正常对照组在选定的保守阈值。Risch λ分析揭示了整个大脑皮质厚度减少的遗传性的广泛证据。据我们所知，本研究提供了第一个证据，广泛分布和遗传减少皮质厚度改变精神分裂症。然而，由于在兄弟姐妹中仅观察到厚度的趋势水平降低，因此皮质厚度本身（至少通过这种方法测量）不是精神分裂症的强中间表型。
Schizophrenia is a brain disorder with predominantly genetic risk factors, and previous research has identified heritable cortical and subcortical reductions in local brain volume. To our knowledge, cortical thickness, a measure of particular interest in schizophrenia, has not previously been evaluated in terms of its heritability in relationship to risk for schizophrenia. To quantify the distribution and heritability of cortical thickness changes in schizophrenia. We analyzed a large sample of normal controls, affected patients, and unaffected siblings using a surface-based approach. Cortical thickness was compared between diagnosis groups on a surfacewide node-by-node basis. Heritability related to disease risk was assessed in regions derived from an automated cortical parcellation algorithm by calculating the Risch λ. Research hospital. One hundred ninety-six normal controls, 115 affected patients with schizophrenia, and 192 unaffected siblings. Regional cortical thickness. Node-by-node mapping statistics revealed widespread thickness reductions in the patient group, most pronouncedly in the frontal lobe and temporal cortex. Unaffected siblings did not significantly differ from normal controls at the chosen conservative threshold. Risch λ analysis revealed widespread evidence for heritability for cortical thickness reductions throughout the brain. To our knowledge, the present study provides the first evidence of broadly distributed and heritable reductions of cortical thickness alterations in schizophrenia. However, since only trend-level reductions of thickness were observed in siblings, cortical thickness per se (at least as measured by this approach) is not a strong intermediate phenotype for schizophrenia.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
17.7
作者：
Callicott, JH;Egan, MF;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
--
作者：
Gogtay, Nitin;Greenstein, Deanna;Rapoport, Judith
通讯作者：
Rapoport, Judith