Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction.
Helicobacter pylori Seropositivity in Patients with Interleukin-1 Polymorphisms Is Significantly Associated with ST-Segment Elevation Myocardial Infarction.
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DOI：
10.1371/journal.pone.0166240
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Hokimoto S
中科院分区：
文献类型：
--
作者：
Tabata N;Sueta D;Akasaka T;Arima Y;Sakamoto K;Yamamoto E;Izumiya Y;Yamamuro M;Tsujita K;Kojima S;Kaikita K;Morita K;Oniki K;Saruwatari J;Nakagawa K;Hokimoto S
幽门螺杆菌感染和白介素1基因多态性与患胃癌的风险增加有关。我们检测了ST段抬高的心肌梗死和非ST段抬高的急性冠脉综合征患者之间幽门螺杆菌血清阳性率和白介素1基因多态性。入选连续入选的急性冠脉综合征患者101例，非ST段抬高急性冠脉综合征患者101例，ST段抬高心肌梗死患者103例。用聚合酶链式反应分析白细胞介素1β-511的单核苷酸多态和白介素1受体拮抗剂的可变数目串联重复序列多态。同时检测抗幽门螺杆菌免疫球蛋白G抗体和超敏C反应蛋白。非ST段抬高急性冠脉综合征组和ST段抬高心肌梗死组IL-1基因多态性和幽门螺杆菌阳性率分别为25.7%和42.7%(P=0.012)。具有IL-1基因多态性的幽门螺杆菌阳性患者的超敏C反应蛋白水平显著高于对照组(P<0.001)。多因素Logistic回归分析显示，幽门螺杆菌阳性和白细胞介素1基因多态性与ST段抬高心肌梗死显著相关(优势比，2.32；95%可信区间，1.23~4.37；P=0.009)。传统危险因素的C统计量为0.68(P<；0.001)，包括幽门螺杆菌血清阳性和白细胞介素1基因多态性的C统计量为0.70(P<；0.001)，持续净分类改善为34%(P=0.0094)，综合辨别能力改善为3.0%(P=0.014)。幽门螺杆菌血清阳性和白细胞介素1基因多态性的重合与超敏C反应蛋白水平升高和ST段抬高心肌梗死风险增加显著相关。
Helicobacter pylori infection and interleukin-1 polymorphisms are associated with an increased risk of gastric cancer. We examined the prevalence of Helicobacter pylori seropositivity and interleukin-1 polymorphisms between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome patients. We recruited consecutive acute coronary syndrome patients, and 101 non-ST-segment elevation acute coronary syndrome patients and 103 ST-segment elevation myocardial infarction patients were enrolled. Interleukin-1 polymorphism analyses were performed for single nucleotide polymorphism in interleukin-1 beta-511 and the variable number of tandem repeats polymorphism in the interleukin-1 receptor antagonist by polymerase chain reaction. Immunoglobulin G antibodies against Helicobacter pylori and high sensitivity C-reactive protein were also measured. The rates of the simultaneous presence of interleukin-1 polymorphisms and Helicobacter pylori-seropositivity between non-ST-segment elevation acute coronary syndrome and ST-segment elevation myocardial infarction groups were 25.7% and 42.7%, respectively (P = 0.012). Helicobacter pylori-seropositive subjects with interleukin-1 polymorphisms showed significantly higher levels of high sensitivity C-reactive protein (0.04–0.12 vs. 0.02–0.05; P<0.001). Multivariate logistic regression analysis revealed that the carriage of Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was significantly associated with ST-segment elevation myocardial infarction (odds ratio, 2.32; 95% confidence interval, 1.23–4.37; P = 0.009). The C-statistic of conventional risk factors was 0.68 (P<0.001) and that including Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was 0.70 (P<0.001); continuous net reclassification improvement was 34% (P = 0.0094) and integrated discrimination improvement was 3.0% (P = 0.014). The coincidence of Helicobacter pylori-seropositivity and interleukin-1 polymorphisms was significantly associated with higher levels of high sensitivity C-reactive protein and the increased risk of ST-segment elevation myocardial infarction.
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影响因子：
24.5
作者：
Beales, ILP;Calam, J
通讯作者：
Calam, J
影响因子：
3.5
作者：
Mather, Adam N.;Fairbairn, Timothy A.;Plein, Sven
通讯作者：
Plein, Sven
DOI：
10.1111/j.1349-7006.2001.tb01106.x
发表时间：
2001-04
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Hamajima N;Matsuo K;Saito T;Tajima K;Okuma K;Yamao K;Tominaga S
通讯作者：
Tominaga S
影响因子：
2.8
作者：
Abbott, J. Dawn;Ahmed, Hanna N.;Williams, David O.
通讯作者：
Williams, David O.
DOI：
10.1073/pnas.93.25.14648
发表时间：
1996-12-10
影响因子：
11.1
作者：
Censini, S;Lange, C;Covacci, A
通讯作者：
Covacci, A