Antivenoms and Coagulation
Antivenoms and Coagulation
复制标题
抗蛇毒血清和凝血
DOI：
10.1007/978-90-481-9295-3_40
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发表时间：
2010
影响因子：
--
通讯作者：
B. Guerrero
中科院分区：
文献类型：
--
作者：
E. Sánchez;A. Rodríguez;Esteban Cantú;B. Guerrero
蛇毒液中毒的治疗是一个复杂的战斗超过世纪。由于抗蛇毒血清的发展，不可避免的致命毒液已减少到很少致命，只要抗蛇毒血清是早期管理。蛇毒含有许多直接作用于咬伤部位的分子，而其他分子则会引发级联反应，导致累积破坏。一个主要的例子是对凝血级联的破坏。毒液分子促进或抑制参与止血系统的分子，引起可导致有害后果的主要干扰。虽然抗蛇毒血清已经存在了很长一段时间，但这些蛇咬伤解毒剂的生产和可用性已经不足。近年来，一些制药公司由于无利可图而停止了抗蛇毒血清的生产，而符合安全标准的严格规定也阻止了其他公司考虑采取这种奋进。医生，科学家，毒物控制和政府管理人员必须做出深刻的努力，共同带来新的想法，这将有助于解决围绕抗蛇毒血清的这些棘手问题。本章的重点是简要介绍毒液成分作用于止血途径和使用和抗蛇毒血清用于中和它们所涉及的问题。
The treatment of snake envenomations has been a complicated battle for over a century. Since the development of antivenoms, inevitably fatal venoms have decreased to rarely fatal provided that antivenom is administered early. Snake venoms contain many molecules that act directly at the site of the bite, while others set off cascades of reactions leading to cumulative disruptions. A primary example is the disruption on the coagulation cascade. Venom molecules promote or inhibit molecules involved in the hemostatic system causing major disturbances that can lead to detrimental consequences. Although antivenoms have been present for a long time, the production and availability of these snakebite antidotes have fallen short. In recent years, some pharmaceutical companies have halted their production of antivenoms due to unprofitable circumstances, and the stringent regulations to meet safety standards have deterred others from considering taking on such an endeavor. Physicians, scientists, poison control and government administrators must make a profound effort to come together to bring in new ideas that will aid in resolving those troubled issues surrounding antivenoms. The focus of this chapter is to briefly address venom components acting on the hemostatic pathway and the use and concerns involved with the antivenoms utilized to neutralize them.
南太平洋响尾蛇（Crotalus oreganus helleri）止血的毒液变异：hellerase 的分离。
DOI：
10.1016/j.cbpc.2008.08.007
发表时间：
2009
期刊：
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
影响因子：
--
作者：
Salazar,AnaMaria;Guerrero,Belsy;Cantu,Bruno;Cantu,Esteban;Rodríguez-Acosta,Alexis;Pérez,JohnC;Galán,JacobA;Tao,Andy;Sánchez,EldaE
通讯作者：
Sánchez,EldaE
大盆地响尾蛇（Crotalus viridis lutosus）毒液生化特征和抗原性的区域差异。
DOI：
10.1016/0305-0491(90)90184-u
发表时间：
1990
期刊：
Comparative biochemistry and physiology. B, Comparative biochemistry
影响因子：
--
作者：
Adame,BL;Soto,JG;Secraw,DJ;Perez,JC;Glenn,JL;Straight,RC
通讯作者：
Straight,RC
DOI：
10.1016/s0041-0101(02)00330-6
发表时间：
2003
期刊：
Toxicon : official journal of the International Society on Toxinology
影响因子：
--
作者：
Sánchez,EldaE;Galán,JacobA;Perez,JohnC;Rodríguez-Acosta,Alexis;Chase,PeterB;Pérez,JohnC
通讯作者：
Pérez,JohnC