The role of Syk/CARD9 coupled C-type lectins in antifungal immunity.
The role of Syk/CARD9 coupled C-type lectins in antifungal immunity.
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DOI：
10.1002/eji.201041252
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发表时间：
2011-02
影响因子：
5.4
通讯作者：
Brown, Gordon D.
中科院分区：
文献类型：
--
作者：
Drummond, Rebecca A.;Saijo, Shinobu;Iwakura, Yoichiro;Brown, Gordon D.
真菌感染正在影响越来越多的人，目前治疗系统性感染的方法失败，导致了令人无法接受的高死亡率。因此，重要的是我们要了解真菌感染期间的免疫机制，以促进辅助免疫疗法的发展，以治疗这些疾病。C型凝集素受体(CLR)是一种模式识别受体(PRRs)，在真菌免疫反应中起关键作用。这些受体中的许多都与Syk激酶偶联，从而允许这些受体通过CARD9发出信号，导致NF-κB激活，进而有助于诱导先天免疫和获得性免疫。Dectin-1、Dectin-2和Mincle都是CLR，它们都具有这种共同的信号机制，并已被证明在抗真菌免疫中发挥关键作用。该综述旨在更新现有的研究范式，并总结关于这些CLR的最新发现、它们的信号转导机制以及这些CLR与其他PRR之间的合作。
Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C-type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF-κB activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin-1, Dectin-2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.
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DOI：
10.4049/jimmunol.1000999
发表时间：
2010-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ni L;Gayet I;Zurawski S;Duluc D;Flamar AL;Li XH;O'Bar A;Clayton S;Palucka AK;Zurawski G;Banchereau J;Oh S
通讯作者：
Oh S
c型凝集素的Dectin-2家族在免疫和稳态中。
影响因子：
3.8
作者：
Graham, Lisa M.;Brown, Gordon D.
通讯作者：
Brown, Gordon D.
影响因子：
4.4
作者：
Kumar, Himanshu;Kumagai, Yutaro;Kawai, Taro
通讯作者：
Kawai, Taro
影响因子：
30.5
作者：
Gringhuis, Sonja I.;den Dunnen, Jeroen;Geijtenbeek, Teunis B. H.
通讯作者：
Geijtenbeek, Teunis B. H.
DOI：
10.1084/jem.20091669
发表时间：
2010-02-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kisand K;Bøe Wolff AS;Podkrajsek KT;Tserel L;Link M;Kisand KV;Ersvaer E;Perheentupa J;Erichsen MM;Bratanic N;Meloni A;Cetani F;Perniola R;Ergun-Longmire B;Maclaren N;Krohn KJ;Pura M;Schalke B;Ströbel P;Leite MI;Battelino T;Husebye ES;Peterson P;Willcox N;Meager A
通讯作者：
Meager A