The Dectin-2 family of C-type lectins in immunity and homeostasis.
The Dectin-2 family of C-type lectins in immunity and homeostasis.
复制标题
c型凝集素的Dectin-2家族在免疫和稳态中。
DOI：
10.1016/j.cyto.2009.07.010
复制
发表时间：
2009-10
期刊：
影响因子：
3.8
通讯作者：
Brown, Gordon D.
中科院分区：
文献类型：
--
作者：
Graham, Lisa M.;Brown, Gordon D.
c型凝集素是一个多样化的蛋白质家族，可识别多种配体。本文综述了c型凝集素Dectin-2家族，包括Dectin-2、BDCA-2、DCIR、DCAR、Clecsf8和Mincle，其基因聚集在小鼠6号染色体和人类12号染色体nk基因簇的端粒区。这些II型受体在髓细胞和非髓细胞上表达，含有单个细胞外碳水化合物识别结构域，在免疫和体内平衡中具有多种功能。DCIR是该家族中唯一含有胞质信号基元的成员，已被证明可作为抑制受体，而BDCA-2、Dectin-2、DCAR和Mincle都与FcRγ链相关，诱导细胞活化，包括吞噬和细胞因子的产生。Dectin-2和Mincle已被证明是真菌的模式识别受体，而DCIR是HIV的附着因子。除了病原体识别外，DCIR已被证明通过控制树突状细胞增殖在预防自身免疫性疾病中起关键作用，而Mincle识别坏死细胞释放的核蛋白。在这里，我们回顾了这些受体的详细描述他们的表达，配体识别，信号和已知的生理功能。
C-type lectins are a diverse family of proteins which recognize a wide range of ligands. This review focuses on the Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes are clustered in the telomeric region of the NK-gene cluster on mouse chromosome 6 and human chromosome 12. These type II receptors are expressed on myeloid and non-myeloid cells and contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRγ chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation, whereas Mincle recognizes a nuclear protein released by necrotic cells. Here we review each of these receptors in detail describing their expression, ligand recognition, signalling and known physiological functions.
登录
查看更多内容
DOI：
10.1042/bj20071216
发表时间：
2008-04-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Christou CM;Pearce AC;Watson AA;Mistry AR;Pollitt AY;Fenton-May AE;Johnson LA;Jackson DG;Watson SP;O'Callaghan CA
通讯作者：
O'Callaghan CA
影响因子：
4.3
作者：
Carter, Robert W.;Thompson, Clare;Tough, David F.
通讯作者：
Tough, David F.
影响因子：
5.4
作者：
Arce, I;Martínez-Muñoz, L;Fernández-Ruiz, E
通讯作者：
Fernández-Ruiz, E
影响因子：
4.4
作者：
Dzionek, A;Fuchs, A;Schmitz, J
通讯作者：
Schmitz, J
影响因子：
2.1
作者：
Huysamen C;Brown GD
通讯作者：
Brown GD