A model of path integration and representation of spatial context in the retrosplenial cortex
A model of path integration and representation of spatial context in the retrosplenial cortex
复制标题
压后皮质的路径整合和空间背景表示模型
作者：
Mingda Ju;P. Gaussier
受最近的生物实验的启发，我们模拟动物在不同的环境（开放空间，螺旋迷宫和跑步机上）中移动，以测试一个简单的模型作为路径整合（PI）和分类机制的压后皮层（RSC）的性能。海马、RSC和内嗅皮层之间的联系通过一个新的视角被揭示。我们假设路径积分是由RSC提供的信息完成的。内嗅皮层中的网格细胞可以作为RSC活动的模投射的结果而建立。在我们的模型中，PI是由一个一维的神经元场作为一个简单的低通滤波器的头方向（HD）细胞调制的线速度的动物。我们的论文集中在HD细胞的形状上的约束，以获得良好的PI近似。在我们的1D PI场上记录神经元显示，这些神经元不会被直观地解释为执行PI。当小鼠在跑步机上跑步时，使用来自我们PI场的狭窄相邻投影的输入在RSC中产生类似于位置细胞的活动。这可能是局部自组织映射的结果，表示RSC中的神经元斑点（例如皮质列）。其他模拟表明，无论环境如何，访问整个PI场都会诱导位置细胞。由于未观察到此属性，因此我们得出结论，RSC中的分类神经元应该只能访问PI字段的一小部分。
Inspired by recent biological experiments, we simulate animals moving in different environments (open space, spiral mazes and on a treadmill) to test the performances of a simple model of the retrosplenial cortex (RSC) acting as a path integration (PI) and as a categorization mechanism. The connection between the hippocampus, RSC and the entorhinal cortex is revealed through a novel perspective. We suppose that the path integration is performed by the information coming from RSC. Grid cells in the entorhinal cortex then can be built as the result of a modulo projection of RSC activity. In our model, PI is performed by a 1D field of neurons acting as a simple low-pass filter of head direction (HD) cells modulated by the linear velocity of the animal. Our paper focuses on the constraints on the HD cells shape for a good approximation of PI. Recording of neurons on our 1D PI field shows these neurons would not be intuitively interpreted as performing PI. Using inputs coming from a narrow neighbouring projection of our PI field creates place cell-like activities in the RSC when the mouse runs on the treadmill. This can be the result of local self-organizing maps representing blobs of neurons in the RSC (e.g. cortical columns). Other simulations show that accessing the whole PI field would induce place cells whatever the environment is. Since this property is not observed, we conclude that the categorization neurons in the RSC should have access to only a small fraction of the PI field.
影响因子：
1.9
作者：
Sharp, PE;Tinkelman, A;Cho, JW
通讯作者：
Cho, JW
解读海马多语言：海马作为路径整合系统。
DOI：
10.1242/jeb.199.1.173
发表时间：
1996
期刊：
The Journal of experimental biology
影响因子：
--
作者：
McNaughton,BL;Barnes,CA;Gerrard,JL;Gothard,K;Jung,MW;Knierim,JJ;Kudrimoti,H;Qin,Y;Skaggs,WE;Suster,M;Weaver,KL
通讯作者：
Weaver,KL