Enterococcus Virulence and Resistant Traits Associated with Its Permanence in the Hospital Environment.

Enterococcus Virulence and Resistant Traits Associated with Its Permanence in the Hospital Environment.
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DOI:
10.3390/antibiotics11070857
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发表时间:
2022-06-26
期刊:
Antibiotics (Basel, Switzerland)
影响因子:
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通讯作者:
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其他
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肠球菌是一种机会致病菌,在临床环境中越来越重要,特别是在医院获得性感染方面。这个问题主要与这样一个事实有关,即这些细菌能够对不同类别的抗生素产生内在和外在的耐药性,其中非常重要的是对万古霉素耐药的肠球菌。然而,其他方面,如不同毒力因子的表达,包括生物被膜形成能力,以及其交易遗传信息的能力,使该细菌属更能在恶劣的环境条件下生存。所有这些特征,以及一些关于某些杀菌剂敏感性降低的报道,都在这篇文献综述中描述了,这些特征使肠球菌在医院环境中表现出更长的生存能力,从而使它们有更多机会在这些环境中传播,并对难以治疗的感染负责。
Enterococcus are opportunistic pathogens that have been gaining importance in the clinical setting, especially in terms of hospital-acquired infections. This problem has mainly been associated with the fact that these bacteria are able to present intrinsic and extrinsic resistance to different classes of antibiotics, with a great deal of importance being attributed to vancomycin-resistant enterococci. However, other aspects, such as the expression of different virulence factors including biofilm-forming ability, and its capacity of trading genetic information, makes this bacterial genus more capable of surviving harsh environmental conditions. All these characteristics, associated with some reports of decreased susceptibility to some biocides, all described in this literary review, allow enterococci to present a longer survival ability in the hospital environment, consequently giving them more opportunities to disseminate in these settings and be responsible for difficult-to-treat infections.
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