Phase separation drives the formation of biomolecular condensates in the immune system.
Phase separation drives the formation of biomolecular condensates in the immune system.
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相分离驱动免疫系统中生物分子凝聚物的形成
DOI：
10.3389/fimmu.2022.986589
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发表时间：
2022
影响因子：
7.3
通讯作者：
Ma, Jian
中科院分区：
文献类型：
--
作者：
Wen, Yuqing;Ma, Jian
当温度或压力等外界条件发生变化时，多组分体系有时会分离成组分和结构不同的多个相，称为相分离。越来越多的研究表明，细胞通过相分离将相关的生物分子浓缩成独立的区室，以便进行有序和有效的生物反应。通过相分离形成的生物分子凝聚物在多种细胞过程中发挥重要作用，包括信号转导的控制、基因表达的调节和应激反应。近年来，在免疫应答过程中发现了许多相分离事件。本文就相分离在先天性免疫和适应性免疫中的作用和机制作一综述，以帮助读者了解这一领域的研究进展和重要性。
When the external conditions change, such as the temperature or the pressure, the multi-component system sometimes separates into several phases with different components and structures, which is called phase separation. Increasing studies have shown that cells condense related biomolecules into independent compartments in order to carry out orderly and efficient biological reactions with the help of phase separation. Biomolecular condensates formed by phase separation play a significant role in a variety of cellular processes, including the control of signal transduction, the regulation of gene expression, and the stress response. In recent years, many phase separation events have been discovered in the immune response process. In this review, we provided a comprehensive and detailed overview of the role and mechanism of phase separation in the innate and adaptive immune responses, which will help the readers to appreciate the advance and importance of this field.
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影响因子：
7.8
作者：
Bjorkoy, Geir;Lamark, Trond;Brech, Andreas;Outzen, Heidi;Perander, Maria;Overvatn, Aud;Stenmark, Harald;Johansen, Terje
通讯作者：
Johansen, Terje
影响因子：
19
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影响因子：
5.4
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Claverie, Jean-Michel
影响因子：
5.4
作者：
Bohnenberger, Hanibal;Oellerich, Thomas;Wienands, Juergen
通讯作者：
Wienands, Juergen
影响因子：
16
作者：
Brown, Jonathan D.;Lin, Charles Y.;Duan, Qiong;Griffin, Gabriel;Federation, Alexander J.;Paranal, Ronald M.;Bair, Steven;Newton, Gail;Lichtman, Andrew H.;Kung, Andrew L.;Yang, Tianlun;Wang, Hong;Luscinskas, Francis W.;Croce, Kevin J.;Bradner, James E.;Plutzky, Jorge
通讯作者：
Plutzky, Jorge